Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty

NCT07598552 | Not Yet Recruiting

• 1 other identifier: 25/49880
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery. The main question it aims to answer is: Does patients experience cognitive changes in cognitive test performance from before surgery to the first day after surgery? Participants will:

• Complete a cognitive test batteri vitually about 14 days before surgery, and on the first and seventh day after their operation.
• Record pain levels and pain medicine use during the first week after surgery

Conditions

Postoperative Cognitive Dysfunction (POCD); Cognitive Change; Total Knee Arthroplasty; Unicompartmental Knee Arthroplasty

Keywords

Same-day discharge; Fast-track surgery; Hip arthroplasty; Knee arthroplasty; Unicompartmental knee arthroplasty; Cognitive function; SDMT; Stroop test; Verbal fluency; Older adults; recovery

Outcome Measures

Primary Outcomes (1)

• Change in Symbol Digit Modality Test (SDMT) score from baseline to postoperative day 1.

  The SDMT is a validated neuropsychological tool that measures processing speed, attention, and visual scanning. The SDMT will be administered virtually as an oral 90-second test. The primary metric will be the SDMT score, defined as the number of correct digit substitutions completed within 90 seconds

  From baseline, 14 days before surgery, and postoperative day 1.

Secondary Outcomes (7)

• Change in Symbol Digit Modality Test (SDMT) score from baseline to postoperative day 7.

  From baseline, 14 days before surgery, and postoperative day 7.

• Change in Stroop Color-Word Test score from baseline to postoperative day 1.

  From baseline, 14 days before surgery, and postoperative day 1.

• Change in Stroop Color-Word Test score from baseline to postoperative day 7.

  From baseline, 14 days before surgery, and postoperative day 7.

• Change in Verbal fluency assessment score from baseline to postoperative day 1.

  From baseline, 14 days before surgery, and postoperative day 1.

• Change in Verbal fluency assessment score from baseline to postoperative day 7.

  From baseline, 14 days before surgery, and postoperative day 1.

Other Outcomes (4)

• Cumulative In-hospital postoperative morphine consumption

  End of surgery until discharge from the hospital on the day 1 of surgery (DOS)

• Cumulated postoperative morphine consumption.

  Postoperative day 1 to postoperative day 7.

• Postoperative pain intensity during rest once a day.

  From postoperative day 1 to postoperative day 7.

Study Arms (3)

Total Hip Arthroplasty

Patients aged 70 years or older undergoing elective unilateral total hip arthroplasty with planned discharge on the day of surgery.

Total Knee Arthroplasty

Patients aged 70 years or older undergoing elective unilateral total knee arthroplasty with planned discharge on the day of surgery.

Unicompartmental Knee Arthroplasty

Patients aged 70 years or older undergoing elective unilateral unicompartmental knee arthroplasty with planned discharge on the day of surgery.

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for hip or knee arthroplasty at Svendborg hospital, Denmark.

You may qualify if:

• Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee
• Native Danish speaker
• Spinal anesthesia

You may not qualify if:

• Inability or unwillingness to provide informed consent
• Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment
• Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20
• Parkinson's disease or other neurological conditions causing functional impairment
• History of alcohol abuse (≥35 units per week)
• Daily use of anxiolytics or hypnotics
• Not discharged on the day of surgery

Sponsors & Collaborators

• Odense University Hospital: lead

Study Sites (1)

Odense University Hospital, Svendborg Hospital

Svendborg, 5700, Denmark

Location

Related Publications (23)

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MeSH Terms

Conditions

Postoperative Cognitive Complications

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognitive Dysfunction; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Martin Lindberg-Larsen, Professor

  Head of Research / Consultant Orthopaedic Surgeon at Odense University Hospital. Department of Clinical Research, University of Southern Denmark (SDU)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Abdullahi Abdirisak Hirsi, MD

CONTACT

+4553376575; abdullahi.abdirisak.hirsi2@rsyd.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: May 14, 2026
• First Posted: May 20, 2026
• Study Start: May 18, 2026
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)