Cohort of Lower-Extremity Sports Injuries and Degeneration(Yongjiang Cohort)

NCT07592871 | Not Yet Recruiting DMC

• 1 other identifier: PJ-NBEY-KY-2026-121-01
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is an observational cohort study conducted at Ningbo No. 2 Hospital. The study will include patients with knee-related sports injuries or degenerative knee conditions who receive routine clinical care. The purpose is to build a standardized real-world clinical cohort and evaluate knee injury, degeneration, recovery, and long-term outcomes. After informed consent, participants will undergo baseline data collection, including medical history, laboratory tests, questionnaires, X-ray and MRI imaging, and functional assessments. Patients younger than 50 years will mainly be assessed for sports injury and functional recovery, while patients aged 50 years or older will receive additional sarcopenia-related assessments such as grip strength, DXA testing, and gait evaluation. No experimental treatment, randomization, or intervention will be assigned. Participants will be followed at about 6, 12, and 24 months after treatment or surgery to assess knee function, imaging changes, reinjury, reoperation, pain, quality of life, falls, and functional decline. The study plans to enroll about 500 participants.

Conditions

Osteoarthritis (OA) of the Knee

Outcome Measures

Primary Outcomes (2)

• Change in Knee Function Scores(IKDC)

  Change in knee function from baseline will be assessed using validated patient-reported outcome scores(IKDC)

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

• Change in Imaging-Based Knee Degeneration(T1/T2 mapping)

  Progression of knee degeneration will be assessed using quantitative MRI sequences ( T1/T2 mapping).

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

Secondary Outcomes (5)

• Change in Knee Function Scores(KOOS)

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

• Change in Knee Function Scores(WOMAC)

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

• Change in Cartilage Morphology on 3D DESS MRI

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

• Change in Proton Density Fat Fraction on Knee MRI

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

• Change in Kellgren-Lawrence Grade on Knee X-ray

  Baseline, 6 months, 12 months, and 24 months after treatment or surgery

Study Arms (2)

Sports Injury Cohort

Participants with knee-related sports injuries as the main clinical condition. This cohort will be observed for injury characteristics, treatment patterns, tissue repair, functional recovery, and subsequent degenerative changes during follow-up.

Other: Routine Clinical Care

Degenerative Knee Disease Cohort

Participants with degenerative knee conditions, including knee osteoarthritis or related degenerative disorders, as the main clinical condition. This cohort will be observed for degeneration severity, symptom burden, imaging progression, body composition, gait changes, and clinical outcomes during follow-up.

Other: Routine Clinical Care

Interventions

Routine Clinical Care OTHER

Participants will receive routine clinical care as determined by their treating physicians according to usual clinical practice. The study will not assign any treatment, randomization, or experimental intervention.

Degenerative Knee Disease Cohort; Sports Injury Cohort

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include patients with knee-related diseases or injuries who receive routine clinical care through the orthopedic and sports medicine outpatient, emergency, and inpatient services at Ningbo No. 2 Hospital. Eligible participants will include patients with sports injuries, degenerative knee conditions, or related knee disorders. Participants will be managed according to routine clinical practice and followed as part of an observational cohort.

You may qualify if:

• Patients who plan to receive relevant clinical evaluation or treatment at Ningbo No. 2 Hospital and are able to complete baseline assessment.
• Patients with a clinical diagnosis of knee-related injury or degenerative knee disease.
• Patients who are willing to provide informed consent and participate in follow-up.

You may not qualify if:

• Patients who are unable to complete the core baseline assessments or have substantial missing key clinical information.
• Patients with severe comorbid conditions or cognitive impairment that may affect assessment of the main outcomes or prevent participation in follow-up.

Sponsors & Collaborators

• Ningbo No.2 Hospital: lead

Related Publications (3)

• Williams AA, Koltsov JCB, Brett A, He J, Chu CR. Using 3D MRI Bone Shape to Predict Pre-Osteoarthritis of the Knee 2 Years After Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2023 Dec;51(14):3677-3686. doi: 10.1177/03635465231207615. Epub 2023 Nov 7.

  PMID: 37936374 BACKGROUND

• Nakanishi Y, Hegarty P, Vivacqua T, Firth A, Milner JS, Pritchett S, Willits K, Litchfield R, Bryant D, Getgood AMJ. Quantitative MRI Analysis of Patellofemoral Joint Cartilage Health 2 Years After Anterior Cruciate Ligament Reconstruction and Lateral Extra-Articular Tenodesis. Am J Sports Med. 2024 Jun;52(7):1773-1783. doi: 10.1177/03635465241248642. Epub 2024 May 25.

  PMID: 38794906 BACKGROUND

• Watanabe S, Joseph GB, Sato D, Lansdown DA, Brandao Guimaraes J, Link TM, Ma CB. Longitudinal Changes in Medial Meniscal Extrusion After ACL Injury and Reconstruction and Its Relationship With Cartilage Degeneration Assessed Using MRI-Based T1rho and T2 Analysis. Am J Sports Med. 2025 Feb;53(2):350-359. doi: 10.1177/03635465241305734. Epub 2025 Jan 2.

  PMID: 39743985 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Yi Yuan, MD

CONTACT

+86 18858234093; yct1124@alumni.sjtu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 2, 2026
• First Posted: May 18, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): May 31, 2028
• Study Completion (Estimated): May 31, 2028
• Last Updated: May 22, 2026

Record last verified: 2026-05