The Effects of Functional Electrical Stimulation (FES) and Exercise on the Quadriceps in Patients With Knee Osteoarthritis

NCT07309003 | Recruiting

• 1 other identifier: TABED 2-24-28
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 2

Brief Summary

In our study, we aimed to compare the effects of functional electrical stimulation (FES) and an exercise program on quadriceps muscle strength and structural characteristics, as well as their impact on gait analysis, pain severity, and quality of life, in order to determine more effective and beneficial treatment programs for patients with knee OA.

Conditions

Osteoarthritis (OA) of the Knee

Keywords

FES; Knee osteoarthritis

Outcome Measures

Primary Outcomes (2)

• Quadriceps muscle strength

  The patients' knee extensor and flexor muscle strengths were evaluated using the Diers Myoline Isometric Muscle Strength Measurement System. After positioning the individuals on the device, their name, surname, age, weight, and height information was recorded. They were then informed about how the test would be conducted and shown videos demonstrating the measurement procedure. For whichever muscle strength was being measured, they were instructed to perform the movement with maximal effort and to hold the muscle contraction isometrically for 10 seconds, after which the results were recorded. Measurement of patients' muscle strength before treatment, on the 10th day, and at the 6th week.

  From enrollment to the end of treatment at 6 weeks

• Visual Analog Scale (VAS)

  Zero indicates no pain at all, while 10 represents the worst possible pain.

  From enrollment to the end of treatment at 6 weeks

Study Arms (2)

FES-Cycling

knee osteoarthritis

Device: functional electrical stimulation (FES)

Cycling

knee osteoarthritis

Interventions

functional electrical stimulation (FES) DEVICE

FES-Cycling

FES-Cycling

Eligibility Criteria

• Age: 50 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients, male or female, aged 50-65, who present to Ankara Bilkent City Hospital Physical Therapy and Rehabilitation Hospital as outpatients, are diagnosed with osteoarthritis classified as Kellgren-Lawrence radiographic stage 2-3, and agree to participate in the study.

You may qualify if:

• Being between 50-65 years of age
• Having knee OA (primary) according to ACR criteria
• Having grade 2-3 knee OA according to the Kellgren-Lawrence classification
• Having the ability to adhere to exercise regimens
• Agreeing to participate in the study

You may not qualify if:

• Having a diagnosis of secondary OA
• History of major knee trauma, surgery, or intra-articular steroid/hyaluronic acid injection in the last 6 months
• Presence of active synovitis
• Presence of neurological (Parkinson's, Alzheimer's, Polyneuropathy), endocrinological (diabetes mellitus), or vestibular disorders that could affect functional status, pain severity, or proprioception; or any disease that impairs these factors
• Pulmonary or cardiovascular disease that contraindicates exercise
• History of fracture and/or surgery in the lower extremity

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (2)

Ankara Bilkent Şehir Hastanesi

Ankara, Ankara, 06800, Turkey (Türkiye)

COMPLETED

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Newham DJ, Donaldson Nde N. FES cycling. Acta Neurochir Suppl. 2007;97(Pt 1):395-402. doi: 10.1007/978-3-211-33079-1_52.

  PMID: 17691402 RESULT

MeSH Terms

Conditions

Osteoarthritis; Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Betül Küçük Gürsoy, MD

CONTACT

+905393828686; betulkucukgursoy@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DOCTOR

Study Record Dates

• First Submitted: November 18, 2025
• First Posted: December 30, 2025
• Study Start: January 3, 2025
• Primary Completion: December 30, 2025
• Study Completion: December 30, 2025
• Last Updated: December 30, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

TU (2)