Effect of Periodontal Therapy on Asprosin in Stable Angina

NCT07591844 | Not Yet Recruiting

• 2 other identifiers: OMU-3065673
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis. Asprosin is a novel metabolic biomarker reported to have potential protective roles in cardiovascular diseases and inflammatory processes. The study also investigates the relationship between periodontal parameters and serum asprosin levels before and after periodontal therapy.

Conditions

Stable Angina Pectoris; Periodontitis

Keywords

Non-surgical periodontal treatment; cardiovascular disease; stable angina; asprosin; periodontitis

Outcome Measures

Primary Outcomes (1)

• Change in serum asprosin levels after non-surgical periodontal therapy

  Serum asprosin concentrations (ng/mL) will be measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit at baseline and 3 months following non-surgical periodontal therapy.

  Baseline and 3 months

Study Arms (3)

Stable angina and periodontitis group (SAP group)

EXPERIMENTAL

Individuals with angiographically confirmed stable angina and periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing

Procedure: Non-surgical periodontal therapy (scaling and root planing)

Periodontitis group (P group)

EXPERIMENTAL

Individuals with angiographically confirmed cardiovascular health and periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing

Procedure: Non-surgical periodontal therapy (scaling and root planing)

Control group (C group)

ACTIVE COMPARATOR

Periodontally healthy individuals with angiographically confirmed absence of coronary artery disease who will receive routine professional dental cleaning and standardized oral hygiene instruction

Procedure: Non-surgical periodontal therapy (Professional dental cleaning)

Interventions

Non-surgical periodontal therapy (scaling and root planing) PROCEDURE

Non-surgical periodontal therapy will include full-mouth scaling and root planing performed using hand instruments and/or ultrasonic devices to remove supra- and subgingival plaque and calculus.

Periodontitis group (P group); Stable angina and periodontitis group (SAP group)

Non-surgical periodontal therapy (Professional dental cleaning) PROCEDURE

Supragingival calculus and plaque removal with standardized oral hygiene instruction.

Control group (C group)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Willingness to participate in the study and provide written informed consent
• Age 18 years or older
• No periodontal treatment within the past 6 months
• No use of local or systemic antibiotics within the past 3 months

You may not qualify if:

• Unwillingness to participate in the study or to provide informed consent
• Age under 18 years
• Use of local or systemic antibiotics for the treatment of widespread infection within the past 3 months
• Receipt of periodontal treatment within the past 6 months
• Pregnancy or lactation (for female participants)
• History of acute myocardial infarction within the past 6 months

Sponsors & Collaborators

• Ondokuz Mayıs University: lead

Study Sites (1)

Ondokuz Mayis University

Samsun, Atakum, 55270, Turkey (Türkiye)

Location

Related Publications (1)

• Gul SNS, Birdal O, Laloglu E. Serum asprosin levels are increased in patients with periodontitis and ST-segment elevation myocardial infarction and correlated with periodontal parameters: A case-control study. J Periodontal Res. 2024 Apr;59(2):259-266. doi: 10.1111/jre.13210. Epub 2023 Nov 20.

  PMID: 37984462 BACKGROUND

MeSH Terms

Conditions

Angina, Stable; Periodontitis; Cardiovascular Diseases; Arachnodactyly

Interventions

Tooth Exfoliation; Root Planing

Condition Hierarchy (Ancestors)

Angina Pectoris; Myocardial Ischemia; Heart Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Limb Deformities, Congenital; Musculoskeletal Abnormalities; Musculoskeletal Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena; Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Study Officials

• Sena Altintas, DDS

  Ondokuz Mayis University Department of Periodontology

  PRINCIPAL INVESTIGATOR

• Feyza Otan Ozden, Prof.

  Ondokuz Mayis University Department of Periodontology

  STUDY DIRECTOR

Central Study Contacts

Sena Altintas, DDS

CONTACT

+905540270097; senaltintas144@gmail.com

Feyza Otan Ozden, Prof.

CONTACT

feyza_otan@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research assistant

Model Details: Stable angina and periodontitis group (SAP group): Individuals diagnosed with stable angina and periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing. Periodontitis group (P group): Cardiovascularly healthy individuals diagnosed with periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing. Control group (C group): Periodontally and cardiovascularly healthy individuals who will receive routine professional dental cleaning and standardized oral hygiene instruction.

Study Record Dates

• First Submitted: May 11, 2026
• First Posted: May 18, 2026
• Study Start: May 20, 2026
• Primary Completion (Estimated): August 20, 2026
• Study Completion (Estimated): October 20, 2026
• Last Updated: May 18, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)