Non-Surgical Periodontal Therapy and Cardiac Biomarkers in Stable Angina

NCT07412795 | Not Yet Recruiting

• 2 other identifiers: OMU-BAP-56735673
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical study is to learn whether gum treatment can improve heart health. Researchers will compare blood markers related to heart disease before and after routine gum treatment. The main questions this study aims to answer are: Is gum disease a risk factor for heart disease? Can treating gum disease lower the risk of heart disease? Adults with stable angina (a type of heart disease) and adults without heart disease may take part in this study. All participants will receive routine, non-surgical gum treatment, which is a standard dental care procedure. This includes professional cleaning to remove plaque and tartar from the teeth and practical education on tooth brushing and cleaning between the teeth. The treatment will be performed by a single researcher and completed in one visit within about one hour. Participants will: Provide a blood sample before gum treatment Receive routine, non-surgical gum treatment Return after three months for a follow-up visit Provide a second blood sample This study does not involve experimental drugs or devices. Participation is voluntary, and there is no cost to participants. The results may help researchers better understand how gum health is related to heart health.

Conditions

Stable Angina; Periodontitis

Keywords

Non-surgical Periodontal Treatment; Cardiovascular Disease; Cardiovascular Biomarkers; stable angina; soluble ST2; periodontitis; IMA

Outcome Measures

Primary Outcomes (1)

• Change in serum ischemia-modified albumin (IMA) concentration after non-surgical periodontal therapy

  Serum ischemia-modified albumin (IMA) concentration measured in nanograms per milliliter (ng/mL) using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Assessed at baseline and 3 months after non-surgical periodontal therapy.

  Baseline and 3 months

Secondary Outcomes (1)

• Change in serum soluble suppression of tumorigenicity 2(sST2) concentration after non-surgical periodontal therapy

  Baseline and 3 months

Study Arms (3)

Stable angina and periodontitis group (SAP group)

EXPERIMENTAL

Individuals diagnosed with stable angina and periodontitis who will receive non-surgical

Procedure: Non-surgical periodontal therapy (scaling and root planing)

Periodontitis group (P group)

EXPERIMENTAL

Cardiovascularly healthy individuals diagnosed with periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing.

Procedure: Non-surgical periodontal therapy (scaling and root planing)

Control group (C group)

ACTIVE COMPARATOR

Periodontally and cardiovascularly healthy individuals who will receive routine professional dental cleaning and standardized oral hygiene instruction.

Procedure: Non-surgical periodontal therapy (Professional dental cleaning)

Interventions

Non-surgical periodontal therapy (scaling and root planing) PROCEDURE

Non-surgical periodontal therapy will include full-mouth scaling and root planing performed using hand instruments and/or ultrasonic devices to remove supra- and subgingival plaque and calculus.

Periodontitis group (P group); Stable angina and periodontitis group (SAP group)

Non-surgical periodontal therapy (Professional dental cleaning) PROCEDURE

Supragingival calculus and plaque removal with standardized oral hygiene instruction.

Control group (C group)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Willingness to participate in the study and provide written informed consent
• Age 18 years or older
• No periodontal treatment within the past 6 months
• No use of local or systemic antibiotics within the past 3 months

You may not qualify if:

• Unwillingness to participate in the study or to provide informed consent
• Age under 18 years
• Use of local or systemic antibiotics for the treatment of widespread infection
• within the past 3 months
• Receipt of periodontal treatment within the past 6 months
• Pregnancy or lactation (for female participants)
• History of acute myocardial infarction within the past 6 months

Sponsors & Collaborators

• Ondokuz Mayıs University: lead

Study Sites (1)

Ondokuz Mayis University

Samsun, Atakum, 55270, Turkey (Türkiye)

Location

Related Publications (2)

• Karci B, Savas HB. Evaluation of thiol/disulfide homeostasis and ischemia modified albumin as potential markers for periodontitis. BMC Oral Health. 2025 Apr 10;25(1):519. doi: 10.1186/s12903-025-05875-w.

  PMID: 40211225 BACKGROUND

• Yilmaz M, He Q, Demir E, Terasjarvi J, Gursoy UK. Salivary IL-33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis. Oral Dis. 2024 May;30(4):2254-2261. doi: 10.1111/odi.14675. Epub 2023 Jul 10.

  PMID: 37427857 BACKGROUND

MeSH Terms

Conditions

Angina, Stable; Periodontitis; Cardiovascular Diseases

Interventions

Tooth Exfoliation; Root Planing

Condition Hierarchy (Ancestors)

Angina Pectoris; Myocardial Ischemia; Heart Diseases; Vascular Diseases; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena; Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Study Officials

• Sena Altintas, DDS

  Ondokuz Mayis University Department of Periodontology

  PRINCIPAL INVESTIGATOR

• Feyza Otan Ozden, Professor

  Ondokuz Mayis University Department of Periodontology

  STUDY DIRECTOR

Central Study Contacts

Sena Altintas, DDS

CONTACT

+905540270097; senaltintas144@gmail.com

Feyza Otan Ozden, Professor

CONTACT

feyza_otan@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research assistant

Model Details: Stable angina and periodontitis group (SAP group): Individuals diagnosed with stable angina and periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing. Periodontitis group (P group): Cardiovascularly healthy individuals diagnosed with periodontitis who will receive non-surgical periodontal therapy, including scaling and root planing. Control group (C group): Periodontally and cardiovascularly healthy individuals who will receive routine professional dental cleaning and standardized oral hygiene instruction.

Study Record Dates

• First Submitted: January 27, 2026
• First Posted: February 17, 2026
• Study Start: February 20, 2026
• Primary Completion (Estimated): June 5, 2026
• Study Completion (Estimated): August 5, 2026
• Last Updated: February 17, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)