Acute Ocular Effects of Cigarette Smoking

NCT07580040 | Recruiting

• 1 other identifier: IstanbulU-2026-3901546
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective study aims to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults. After baseline examinations and measurements are taken in both smoking and non-smoking participants, the same measurements will be repeated after 10 minutes of external exposure, and within-group and between-group changes will be compared. The aim of the study is to determine whether acute smoking exposure leads to measurable immediate changes in corneal tomographic and biometric parameters.

Conditions

Smoking ( Cigarette); Cornea; Anterior Eye Segment Measurements

Keywords

Cigarette Smoking; Corneal Tomography; Biometry; Pentacam; Anterior Segment; Corneal Densitometry

Outcome Measures

Primary Outcomes (1)

• Change in Pentacam-measured corneal pachymetry at the pupil center after acute cigarette smoking exposure

  Change (post-exposure minus baseline) in corneal pachymetry at the pupil center, measured in micrometers (µm) using Pentacam. The magnitude of change will be compared between smokers and non-smokers.

  Baseline and immediately after a standardized 10-minute outdoor exposure period

Secondary Outcomes (1)

• Change in Pentacam-measured corneal densitometry in the anterior 0-2 mm zone after acute cigarette smoking exposure

  Baseline and immediately after a standardized 10-minute outdoor exposure period

Study Arms (2)

Smokers

Healthy adult participants with active cigarette smoking exposure who underwent baseline ophthalmic examination and Pentacam measurements, followed by repeat measurements after a standardized 10-minute outdoor period during which they smoked.

Other: Cigarette Smoking Exposure

Non-smokers

Healthy adult participants without cigarette smoking exposure who underwent baseline ophthalmic examination and Pentacam measurements, followed by repeat measurements after a standardized 10-minute outdoor period under the same environmental conditions without smoking.

Other: No Smoking Exposure

Interventions

Cigarette Smoking Exposure OTHER

Participants in the smoking group smoked cigarettes during a standardized 10-minute outdoor period between baseline and post-exposure assessments.

Smokers

No Smoking Exposure OTHER

Participants in the control group remained in the same outdoor environment for 10 minutes without smoking between baseline and post-exposure assessments.

Non-smokers

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adult smokers and non-smokers aged 18 to 60 years are planned to be included in this single-center study.

You may qualify if:

• Healthy adults aged 18 to 60 years
• Current smokers in the smoking group
• Never-smokers in the control group
• Willing and able to undergo ophthalmic examination and Pentacam AXL measurements

You may not qualify if:

• History of ocular surgery or ocular trauma
• Presence of corneal disease, retinal disease, or ocular surface disorder
• Clinically significant dry eye disease
• Contact lens use within the last 2 weeks
• Use of medications that may affect the ocular surface or pupillary dynamics, including anticholinergics or sympathomimetics
• Systemic diseases such as diabetes mellitus or hypertension
• Former smoking history in the control group
• Use of electronic cigarettes or other tobacco products
• Inability to cooperate adequately for accurate measurement

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul University, Istanbul Faculty of Medicine

Istanbul, 34093, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Cigarette Smoking; Corneal Diseases

Condition Hierarchy (Ancestors)

Tobacco Smoking; Smoking; Behavior; Tobacco Use; Eye Diseases

Study Officials

• Semih Çakmak

  Istanbul University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Semih Çakmak

CONTACT

902124142000; semihcakmak@istanbul.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 17, 2026
• First Posted: May 12, 2026
• Study Start: February 15, 2026
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)