Quantifying Blood Flow in the Aorta
AF-4DMRI-P2
2 other identifiers
observational
70
1 country
1
Brief Summary
This study aims to gain insights into aortic blood flow in healthy volunteers using PC 4D-flow MRI
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 17, 2026
CompletedFirst Posted
Study publicly available on registry
May 11, 2026
CompletedStudy Start
First participant enrolled
June 1, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2026
Study Completion
Last participant's last visit for all outcomes
July 31, 2027
May 11, 2026
May 1, 2026
2 months
March 17, 2026
May 4, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Aortic blood flow velocity fields
Velocity fields will be acquired, consisting of vectors that describe the velocity magnitude (cm/s) and direction (dimensionless) of blood flow in the aorta. For visualisation purposes, arrows will be used to overlay the shape of the volunteers aorta. Colours of the arrrows indicate the velocity magnitude and direction of the arrows inicate the direction of flow. Velocity fields are generated for the the full aorta, from the ascending aorta to internal/external iliac arteries, including branched arteries such as subclavian arteries, common carotid artery, and visceral branch vessels.
Day 1
Secondary Outcomes (11)
Age of volunteer
Day 1
Gender of volunteer
Day 1
Height of volunteer
Day 1
Weight of volunteer
Day 1
Aortic blood flow waveforms
Day 1
- +6 more secondary outcomes
Study Arms (7)
Group 1
Five men aged 18-25 and five women aged 18-25
Group 2
Five men aged 26-35 and five women aged 26-35
Group 3
Five men aged 36-45 and five women aged 36-45
Group 4
Five men aged 46-55 and five women aged 46-55
Group 5
Five men aged 56-65 and five women aged 56-65
Group 6
Five men aged 66-75 and five women aged 66-75
Group 7
Five men aged 76-85 and five women aged 76-85
Interventions
Subjects fill in a questionnaire regarding their weight, height, age and gender. They also fill in a safety check form to test if MRI can be applied safely.
Subjects will undergo MRI scans of the thorax and abdomen from which we will derive aortic blood flow velocity fields. This intervention will be performed in the same manner on all groups.
Eligibility Criteria
Healthy subjects with no known cardiovascular disease or history thereof
You may qualify if:
- Healthy (in particular without any cardiovascular disease or history thereof) men or women
- years of age or above;
- BMI ≤ 30;
- Willingness to undergo MRI scans;
- Able to provide signed informed consent (IC)
You may not qualify if:
- Irregular heartbeat.;
- Any history of cardiovascular disease or current cardiovascular disease;
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
TechMed centre, University of Twente
Enschede, Overijssel, 7522 NH, Netherlands
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michel M.P.J. Reijnen, prof. dr.
University of Twente
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Coordinating investigator
Study Record Dates
First Submitted
March 17, 2026
First Posted
May 11, 2026
Study Start (Estimated)
June 1, 2026
Primary Completion (Estimated)
July 31, 2026
Study Completion (Estimated)
July 31, 2027
Last Updated
May 11, 2026
Record last verified: 2026-05