Dietary Interventions in the Secondary Prevention of Myocardial Infarction: Focus on Plant-Based Nutrition

NCT07576400 | Completed

• 1 other identifier: 2V/2021
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate whether short-term dietary interventions can improve cardiometabolic risk factors in patients after myocardial infarction. The study includes adult patients following myocardial infarction. The main questions it aims to answer are:

• Does adherence to an ESC-recommended diet lead to improvements in lipid profile and body composition compared with no dietary intervention?
• Does a plant-based (vegan) diet lead to similar or greater improvements in cardiometabolic parameters compared with the control group? Researchers will compare the ESC diet group and the plant-based diet group with a control group to assess their effects on body mass index, lipid profile, and inflammatory markers. Participants will:
• be assigned to one of three groups (ESC diet, plant-based diet, or control),
• receive dietary counselling according to their assigned group (intervention groups),
• follow the assigned dietary pattern for 3 months,
• undergo baseline and follow-up clinical and laboratory assessments, including anthropometric measurements and blood sampling.

Conditions

Myocardial Infarction First

Keywords

Myocardial Infarction; Plant based diet; Diet recommended European Society of Cardiology

Outcome Measures

Primary Outcomes (2)

• Percentage of participants enrolled in the study

  In percentage terms, the number of patients contacted and the proportion of those who were subsequently enrolled.

  48 months

• Percentage of participants completed the study

  Percentage of the enrolled patients completed the study.

  3 month

Secondary Outcomes (25)

• Changes in weight after diet changes

  3 months

• Changes in viceral fat area after diet changes

  3 month

• Changes in skeletal muscle mass after diet changes

  3 month

• Changes in body fat mass after diet changes

  3 month

• Changes in total body water after diet changes

  3 month

Study Arms (3)

Plant based diet

EXPERIMENTAL

The intervention arm, in which participants switch to a strictly plant-based (vegan) diet for three months.

Other: Plant based diet

Diet based on the recommendations of the European Society of Cardiology

EXPERIMENTAL

The intervention arm, in which participants switch to a diet based on the recommendations of the European Society of Cardiology for three months.

Other: Diet based on the recommendations of the European Society of Cardiology

Control arm

NO INTERVENTION

Patients who declined dietary modification but agreed to undergo study assessments were included as a parallel, non-intervention control group.

Interventions

Plant based diet OTHER

Change dietary habits for tree months

Plant based diet

Diet based on the recommendations of the European Society of Cardiology OTHER

Change dietary habits for tree months

Diet based on the recommendations of the European Society of Cardiology

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Myocardial Infarction First

You may not qualify if:

• Myocardial Infarction Second
• Age under 18

Sponsors & Collaborators

• Radana Dymáčková: lead
• Masaryk University: collaborator

Study Sites (1)

Masaryk university

Brno, 62500, Czechia

Location

MeSH Terms

Conditions

Myocardial Infarction

Interventions

Diet, Plant-Based

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Msc. Dagmar Struncova

Model Details: Participants who agreed to change their dietary habits were randomized in a 1:1 ratio into two intervention groups using stratified block randomization according to diabetes mellitus status and smoking status. Group A followed a diet based on the recommendations of the European Society of Cardiology (ESC), while Group B adopted a strictly plant-based (vegan) diet. Patients who declined dietary modification but agreed to undergo study assessments were included as a parallel, non-intervention control group (Group C), based on patient preference.

Study Record Dates

• First Submitted: April 8, 2026
• First Posted: May 8, 2026
• Study Start: January 20, 2022
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: May 8, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)