NCT07574801

Brief Summary

To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
4mo left

Started May 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress6%
May 2026Sep 2026

First Submitted

Initial submission to the registry

April 26, 2026

Completed
5 days until next milestone

Study Start

First participant enrolled

May 1, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

May 8, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Expected
7 days until next milestone

Study Completion

Last participant's last visit for all outcomes

September 8, 2026

Last Updated

May 8, 2026

Status Verified

May 1, 2026

Enrollment Period

4 months

First QC Date

April 26, 2026

Last Update Submit

May 3, 2026

Conditions

Root Canal TreatmentIrreversible Acute Pulpitis

Keywords

postoperative painbioceramic sealerextrusionroot canal treatment

Outcome Measures

Primary Outcomes (1)

  • postoperative pain

    postoperative pain will be measured using a visual analogue scale ( after being introduced and discussed with the patient) at 2 time points, pain will be categorized as no pain, moderate and severe.

    24 and 48 hours

Secondary Outcomes (1)

  • sealer extrusion

    immediate postoperatively

Study Arms (2)

nanosealer flo

EXPERIMENTAL

bioceramic sealer

Procedure: root canal treatment

ceraseal

ACTIVE COMPARATOR

bioceramic sealer

Procedure: root canal treatment

Interventions

root canal treatmentPROCEDURE

nanosealer flo bioceramic root canal sealer

nanosealer flo

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Molar teeth requiring root canal treatment
  • Diagnosed with symptomatic irreversible pulpitis,
  • Patients able to understand and use the VAS scale

You may not qualify if:

  • Patients with systemic diseases affecting pain perception
  • Use of analgesics within 12 hours before treatment
  • Previously treated teeth
  • Teeth with periapical abscess or swelling

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Links

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Central Study Contacts

Sara Gamal Elgamal

CONTACT

00201094557105sara.elgamal@dentistry.cu.edu.eg

Heba ibrahim Mohammady

CONTACT

heba.mohamdy@dentistry.cu.edu.eg

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
clinical ass. professor, principal investigator, endodontic department

Study Record Dates

First Submitted

April 26, 2026

First Posted

May 8, 2026

Study Start

May 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 8, 2026

Last Updated

May 8, 2026

Record last verified: 2026-05