Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up

NCT07246174 | Completed

• 1 other identifier: E-10840098-772.02-243
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this research was to identify which of the root canal sealers, AH Plus or WellRootST, yielded more effective outcomes regarding postoperative pain when applied to teeth diagnosed with apical periodontitis.

Conditions

Root Canal Treatment

Keywords

epoxy-resin-based root canal sealers; Calcium silicate-based root canal sealer; postoperative pain; Visual Analog Scale

Outcome Measures

Primary Outcomes (1)

• postoperative pain evaluation by VAS scale

  Study groups were compared in terms of VAS scores at the preoperative period and postoperative 24 hours, 48 hours, 72 hours, 1 week, and 1 month

  Baseline, 24 hour postoperatively, 48hour postoperatively, 72 hour postoperatively, Day 3 and Day 7

Study Arms (2)

AhPlus sealer

EXPERIMENTAL

AH Plus sealer used

Procedure: AH-Plus Epoxy Resin Sealer

WellRootST sealer

EXPERIMENTAL

WellRootST sealer used

Procedure: bioceramic sealer

Interventions

AH-Plus Epoxy Resin Sealer PROCEDURE

AhPlus sealer was used for group 1

AhPlus sealer

bioceramic sealer PROCEDURE

WellRootSt wa used for group 2

WellRootST sealer

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants had to be at least 18 years old
• One mature tooth showing signs or symptoms that required primary root canal treatment.
• Participants needed to be in good general health
• classified as ASA I or II, and able to follow the follow-up schedule.

You may not qualify if:

• Included teeth with internal or external root resorption,
• Signs of perforation
• The need for post-core application, or previous restoration with fixed prosthetic appliances, such as crowns or bridges

Sponsors & Collaborators

• Medipol University: lead

Study Sites (1)

Istanbul Medipol University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Furkan S Bilgi, PhD

  Medipol University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 24, 2025
• Study Start: January 1, 2024
• Primary Completion: November 1, 2024
• Study Completion: December 31, 2024
• Last Updated: November 24, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: After the acceptance of our study
• Access Criteria: Our data will be shared via email

Locations

TU (1)