Association of Apical Periodontitis With Hs-CRP and Hemogram Indices

NCT04980768 | Unknown

• 1 other identifier: AP & Systemic Markers
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

There is lack of evidence on resolution of signs of systemic inflammatory markers by successful elimination of periapical inflammation by endodontic treatment. Complete blood count (CBC) may have potential to detect various inflammatory conditions but its use for this purpose is sparsely reported. To the best of our knowledge effect of chronic apical periodontitis on various parameters of complete blood count has not been studied.

Conditions

Periapical Periodontitis

Keywords

Apical periodontitis; hsCRP; root canal treatment; hemogram; inflammation

Outcome Measures

Primary Outcomes (2)

• Level of hs-CRP

  Serum level of hs-CRP will be measured using ELISA in g/dl.

  Baseline-3 months

• Hemogram indices

  Complete hemogram parameters in percentage will be assessed using automated machine.

  Baseline-3 months

Study Arms (1)

Root canal treatment

OTHER

Root canal treatment will be provided to all the participants with the diagnosis of apical periodontitis.

Procedure: Root canal treatment

Interventions

Root canal treatment PROCEDURE

Patients with apical periodontitis will undergo root canal treatment.

Root canal treatment

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Pulpal necrosis in mature mandibular molar as confirmed by negative response to pulp sensibility test (cold and electric pulp test)
• Radiographic evidence of apical periodontitis in the form of periapical radiolucency
• Radiographic alveolar bone breakdown not more than one third of root length.

You may not qualify if:

• Obese (BMI \>30 kg/m2), smoker, pregnant, diabetic, immunocompromised or have any other systemic inflammatory condition.
• Having a positive history of antibiotic use within the past month or require antibiotic premedication for dental treatment (including infective endocarditis or prosthetic joint prophylaxis).
• Teeth having previous root fillings, unrestorable teeth, fractured/perforated roots, grade 3 mobility, and history of recent periodontal therapy (within previous 6 months).
• Teeth with established endodontic-periodontal lesions exhibiting \<2 mm radiopaque bone between the root apex.

Sponsors & Collaborators

• Postgraduate Institute of Dental Sciences Rohtak: lead

Study Sites (1)

PGIDS

Rohtak, Haryana, 124001, India

Location

MeSH Terms

Conditions

Periapical Periodontitis; Inflammation

Condition Hierarchy (Ancestors)

Periapical Diseases; Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 4, 2021
• First Posted: July 28, 2021
• Study Start: February 1, 2021
• Primary Completion: August 1, 2021
• Study Completion: November 30, 2021
• Last Updated: July 28, 2021

Record last verified: 2021-07

Locations

IN (1)