Adherence to Enteral Nutrition

NCT07571564 | Recruiting

• 1 other identifier: DATA25024 ADHENUTE
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Malnutrition is a major challenge in cancer nutrition, affecting approximately 40% of cancer patients and having negative consequences on treatment efficacy, quality of life, and prognosis. It must be detected and managed early, based on clinical and laboratory criteria defined by the HAS recommendations. To address this, several nutritional strategies are available, ranging from fortified oral feeding to artificial nutrition. Enteral nutrition, which is more physiological and carries fewer risks than parenteral nutrition, is recommended as the first-line treatment. Tools such as personalized care plans and guidelines help tailor patient care. However, enteral nutrition remains underutilized in clinical practice, despite the recommendations. The ADHENUTE study, conducted at the Institut Curie, showed low compliance with recommendations (31%) and a tendency to favor oral nutritional supplements, even in severely malnourished patients. The lack of traceability of decisions makes it difficult to identify barriers, although patient refusal is sometimes mentioned. To improve this situation, corrective measures have been implemented:

• for patients, through educational workshops to help them better understand and accept enteral nutrition;
• for healthcare providers, through training sessions to address reservations and enhance knowledge. A third phase of the study aims to evaluate the impact of these actions, with the goal of increasing adherence to recommendations and the use of enteral nutrition.

Conditions

Enteral Nutrition

Keywords

enteral nutrition; adherence to enteral nutrition; compliance with enteral nutrition guidelines; malnutrition; nutritional supplements; patient education workshops; training for healthcare staff

Outcome Measures

Primary Outcomes (1)

• Assess compliance with recommendations for the implementation of enteral nutrition following the improvement measures implemented in Phase 2.

  Percentage of patients for whom the recommendations are followed. Compliance with the recommendations will be assessed by comparing the recommended nutritional interventions with those actually implemented.

  From enrollment to the end of follow-up, which is 6 months

Secondary Outcomes (10)

• Assess the traceability of the reasons for not following a recommendation to initiate enteral nutrition in the patient's medical record

  From enrollment to the end of follow-up, which is 6 months

• Assess the role of the dietetics department in screening for malnutrition and in the implementation of enteral nutrition

  From enrollment to the end of follow-up, which is 6 months

• Assess the delay in initiating enteral nutrition

  Since the onset of the disease at the start of enteral nutrition

• Evaluate the implementation of recommendations based on tumor location

  From enrollment to the end of follow-up, which is 6 months

• Identify other nutritional support methods used as alternatives to enteral nutrition.

  From enrollment to the end of follow-up, which is 6 months

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We propose to conduct a prospective, single-center cohort study involving 80 patients. Patients will be enrolled at the Institut Curie in Saint Cloud over a 12-month period and followed for 6 months. Patients must be adults and hospitalized in a medical oncology ward.

You may qualify if:

• Patients hospitalized (including those in the day hospital) in a medical oncology unit;
• Adults;
• Men or women;
• Patients for whom enteral nutrition is indicated according to SFNCM recommendations;

You may not qualify if:

• Minors (under 18 years of age)
• Patients receiving end-of-life palliative care
• Individuals deprived of their liberty or under legal guardianship (including conservatorship);
• Adults under judicial protection;
• Inability to participate in the study for geographical, social, or psychological reasons.
• Persons referred to in Articles L. 1121-5 through L. 1121-8 and L. 1122-1-2 of the Public Health Code (e.g., minors, adults under guardianship, etc.).
• Patients who do not speak or understand French.

Sponsors & Collaborators

• Institut Curie: lead

Study Sites (1)

Institut Curie

Paris, 75248, France

RECRUITING

MeSH Terms

Conditions

Malnutrition

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases

Central Study Contacts

Betty PEIGNELIN

CONTACT

+33 1 47 11 15 24; betty.peignelin@curie.fr

Morgane TOUBON

CONTACT

+33 1 47 11 15 75; morgane.toubon@curie.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 6, 2026
• Study Start: March 5, 2026
• Primary Completion (Estimated): September 4, 2027
• Study Completion (Estimated): September 4, 2027
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

FR (1)