Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension

NCT07565025 | Not Yet Recruiting

• 1 other identifier: 2026/217
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia. Researchers will measure the diameter of the internal jugular vein in patients before surgery and compare these measurements with the blood pressure changes during the first minutes of anesthesia. The goal is to determine if IJV-CI can be used as a reliable, non-invasive tool to identify patients at higher risk of developing anesthesia-induced hypotension.

Conditions

Hypotension; Anesthesia, General; Cholecystectomy, Laparoscopic

Keywords

Internal Jugular Vein; Collapsibility Index; IJV-CI; Ultrasonography; Post-induction Hypotension; Anesthesia Induction; Laparoscopic Cholecystectomy; Fluid Responsiveness

Outcome Measures

Primary Outcomes (1)

• Internal Jugular Vein Collapsibility Index (IJV-CI)

  Hypotension is defined as a decrease in Mean Arterial Pressure (MAP) of more than 20% from the baseline value. The predictive value of pre-induction IJV-CI for this occurrence will be assessed.Measurements will be recorded at 0, 1, 2, 3, 5, 7, 9, and 10 minutes following induction, but will stop if surgical incision occurs earlier than 10 minutes

  Baseline (pre-induction) and every minute up to 10 minutes following induction or until surgical in

Study Arms (2)

Hypotensive Group

Patients who developed post-induction hypotension (MAP decrease \>20% or SBP \<90 mmHg). Pre-induction Internal Jugular Vein (IJV) ultrasonography was performed for statistical comparison.

Diagnostic Test: IJV-CI Measurement

Non-hypotensive Group

Patients aged 18-65 scheduled for elective laparoscopic cholecystectomy who remained hemodynamically stable (no MAP decrease \>20% or SBP \<90 mmHg) after standard anesthesia induction. Pre-induction IJV measurement was performed to evaluate its predictive capacity."

Diagnostic Test: IJV-CI Measurement

Interventions

IJV-CI Measurement DIAGNOSTIC_TEST

Pre-induction Internal Jugular Vein (IJV) measurement will be performed using a linear ultrasound probe (5-12 MHz) while the patient is in the supine position. The IJV will be imaged in the transverse plane at the level of the cricoid cartilage. During spontaneous breathing, the maximum and minimum diameters of the vein will be recorded. The Collapsibility Index (IJV-CI) will be calculated using these measurements. This non-invasive assessment is performed immediately before the induction of general anesthesia to evaluate its predictive value for post-induction hypotension.

Also known as: IJV-CI, Internal Jugular Vein Collapsibility Index, IJV Ultrasonography

Hypotensive Group; Non-hypotensive Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients aged 18-65 who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia. Participants will be selected from patients who meet the ASA I-III physical status criteria. The study focuses on evaluating pre-induction internal jugular vein characteristics using routine clinical monitoring data in a perioperative setting.

You may qualify if:

• Patients aged 18-65 years.
• Patients with ASA (American Society of Anesthesiologists) physical status I, II, or III.
• Patients scheduled to receive general anesthesia.
• Patients scheduled for elective laparoscopic cholecystectomy.

You may not qualify if:

• Patients with obesity (Body Mass Index \> 35 kg/m²).
• Patients with Atrial Fibrillation or other serious cardiac arrhythmias.
• Patients with a history of neck surgery or any pathology preventing Internal Jugular Vein (IJV) measurement.
• Patients with advanced heart failure (Ejection Fraction \< 40%).
• Patients with severe valvular heart disease.
• Patients with peripheral vascular disease.
• Patients undergoing emergency surgery.
• Patients who are unwilling to participate in the study.

Sponsors & Collaborators

• University of Gaziantep: lead

Study Sites (1)

Gaziantep University Sahinbey Research and Training Hospital

Gaziantep, 27310, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hypotension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• ELZEM ŞEN, Associate Professor

  Gaziantep University, Faculty of Medicine, Department of Anesthesiology and Reanimation

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ELZEM ŞEN, Associate Professor

CONTACT

+90 (532) 784 21 52; drelzem@hotmail.com

Kübra Bahar Türkmen, MD

CONTACT

+90 (534) 061 74 44; kbrabaharr@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 27, 2026
• First Posted: May 4, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)