100-Year Human Aging Study

NCT07563777 | Recruiting

• 3 other identifiers: 100YearIORG0012336IRB00014601
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed and mobile clinical sites to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.

Conditions

Aging; Frailty; Neuro-Degenerative Disease; Dementia; Aging Well; All-Cause Mortality; Mortality; Metabolic Syndrome; Cardiovascular Diseases; Cognitive Dysfunction; Musculoskeletal Diseases; Neoplasms; Activities of Daily Living; Health-Related Quality of Life; Disability Physical

Keywords

Longevity; Cardiopulmonary Exercise Testing; Body Composition; Preventive Medicine; Surrogate Endpoint Validation; Mortality Prediction; Functional Decline; Healthspan; Life Expectancy; Biological Aging; Preventive Screening; Longitudinal Cohort; Biomarker Validation; Human Performance; Population Health; Centenarian

Outcome Measures

Primary Outcomes (2)

• All-Cause Mortality

  Vital status ascertained through longitudinal follow-up contact, mortality record linkage, and health data network linkage using probabilistic matching on name, date of birth, and address history.

  From enrollment until death, assessed periodically, up to 100 years

• Cause-Specific Mortality

  Cause of death ascertained via death certificate and mortality record linkage.

  From enrollment until death, assessed periodically, up to 100 years

Secondary Outcomes (7)

• Cause-Specific Mortality Prediction Accuracy

  From enrollment until death, assessed periodically, up to 100 years

• Incident Serious Adverse Health Events

  Periodically from enrollment until death, up to 100 years

• Incident Chronic Disease

  Periodically from enrollment until death, up to 100 years

• Functional Independence and Disability Status

  Periodically from enrollment until death, up to 100 years

• Biological Age Estimate Prediction Accuracy

  Periodically from enrollment until death, up to 100 years

Interventions

Comprehensive Multi-System Clinical Screening DIAGNOSTIC_TEST

Comprehensive multi-system clinical screening battery including cardiopulmonary exercise testing, body composition assessment by DEXA, echocardiography, electrocardiography, spirometry, neurocognitive testing, sensory assessment, metabolic testing, physical examination, and detailed medical, social, occupational, and environmental history. Participants receive individualized clinical findings and investigational longevity constructs at the conclusion of screening.

Also known as: Your Longevity Report Card

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants of all ages, health statuses, and demographic backgrounds presenting for comprehensive preventive health screening at fixed or mobile clinical sites. No exclusions based on health status, geographic location, language, or population group. Participants with limited decision-making capacity may be enrolled with consent from a legally authorized representative. The study actively seeks to enroll participants across the full human lifespan including older adults and centenarians.

You may qualify if:

• Age 18 years or older
• Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative
• Willing to participate in longitudinal follow-up

You may not qualify if:

• Pregnancy
• Age under 18 years

Sponsors & Collaborators

• Longevity Metrics, Inc.: lead

Study Sites (1)

Longevity Metrics

Boulder, Colorado, 80301, United States

RECRUITING

Related Links

• study website

MeSH Terms

Conditions

Metabolic Syndrome; Cardiovascular Diseases; Cognitive Dysfunction; Musculoskeletal Diseases; Neoplasms; Frailty; Dementia

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• William E Brandenburg, MD

  Longevity Metrics, Inc.

  PRINCIPAL INVESTIGATOR

Central Study Contacts

William E Brandenburg, MD

CONTACT

3035010016; info@longevitymetrics.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Founder & CEO

Study Record Dates

• First Submitted: April 11, 2026
• First Posted: May 4, 2026
• Study Start: February 9, 2025
• Primary Completion (Estimated): December 31, 2099
• Study Completion (Estimated): December 31, 2099
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)