Morphological-Gene-Clinical Phenotype Correlation Study of the Long Anterior Zonule

NCT07549711 | Enrolling By Invitation

• 1 other identifier: FZYKYY-KY-2025-005
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

Long anterior zonules (LAZ) is an anatomical anomaly of the anterior segment in which zonular fibers extend abnormally forward onto the anterior lens capsule. It is potentially associated with glaucoma, late-onset retinal degeneration, and increased risks during cataract surgery. This study introduces a 3D visualization system to enhance the detection rate of LAZ. By integrating multiple imaging modalities, it systematically assesses the morphological characteristics of LAZ, aiming to provide an evidence-based foundation for subsequent efforts to establish diagnostic consensus, optimize preoperative assessments for glaucoma and cataract surgery. By elucidating the genetic mechanisms and genotype-phenotype correlations of LAZ, this research can provide theoretical support for the early identification of high-risk populations, genetic consultation, and personalized treatment.

Conditions

Long Anterior Zonules

Outcome Measures

Primary Outcomes (7)

• Axial length

  Axial length, anterior chamber depth, lens thickness, corneal curvature, corneal diameter

  1 day pre-op

• Anterior chamber depth

  1 day pre-op

• Lens thickness

  1 day pre-op

• Corneal curvature

  1 day pre-op

• Corneal diameter (WTW)

  1 day pre-op

• Imaging of LAZ morphology and distribution

  The images and videos about slit lamp and 3D visualization system.

  1 day pre-op

• Gene sequencing

  Identification of pathogenic genes

  through study completion, an average of 1 year

Secondary Outcomes (13)

• Uncorrected Visual Acuity (UCVA)

  1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op

• Corrected Distance Visual Acuity (CDVA)

  1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op

• Spherical equivalent (SE)

  1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op

• Intraocular pressure

  1 day pre-op; 1 day post-op; 7 days post-op; 30 days post-op

• Intraoperative complications

  Intraoperative

Study Arms (3)

Control Group

Genetic: Control

LAZ Group

Genetic: Long anterior zonules

LAZ Pedigree Cohort

Genetic: LAZ Pedigree

Interventions

Control GENETIC

Routine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure.

Control Group

Long anterior zonules GENETIC

Patients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ.

LAZ Group

LAZ Pedigree GENETIC

First-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.

LAZ Pedigree Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

LAZ (Long anterior zonules) is characterized by the abnormal anterior extension of the ciliary zonule fibers, resulting in a significant reduction in the diameter of the central zonule-free zone of the lens.

You may qualify if:

• Control Group Routine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure.
• LAZ Group Patients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ.
• LAZ Pedigree Cohort First-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.

You may not qualify if:

• Secondary glaucoma with a clear etiology (such as inflammatory, traumatic, or neovascular glaucoma, etc.)
• History of previous intraocular surgery (e.g., cataract, glaucoma, or vitreoretinal surgery), with refractive surgery history documented but analyzed with caution
• Presence of ocular conditions affecting anterior segment imaging quality, such as corneal leukoma or severe cataract
• Individuals with severe systemic diseases (e.g., poorly controlled diabetes, connective tissue diseases) or mental disorders that hinder cooperation during examinations
• Pregnant or lactating women.

Sponsors & Collaborators

• Fuzhou Eye Hospital: lead

Study Sites (1)

Fuzhou Eye Hospital

Fuzhou, Fujian, 350007, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

anterior lens capsule, peripheral venous blood

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: April 24, 2026
• Study Start: January 10, 2025
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: April 24, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)