NCT06652594

Brief Summary

This is a randomized controlled trial aimed to explore the effect of behavioral interventions based on doctors' and nurses' health education on the onset and development of myopia in children's. Participants were randomly assigned to one of two groups: eye health intervention, or the control group. Intervention group's parents would reveive eye health education in response to their children's myopia progression at baseline, 1 month, 3 months, and 6 months, while the control group did not receive any. Visual acuity, cycloplegic refraction, axial length, Strengths and Difficulties Questionnaire, and Generalized Anxiety Disorder 7-item Scale were the main outcomes and measures.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
498

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 19, 2024

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

October 21, 2024

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 22, 2024

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 19, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 19, 2025

Completed
Last Updated

October 22, 2024

Status Verified

October 1, 2024

Enrollment Period

6 months

First QC Date

October 21, 2024

Last Update Submit

October 21, 2024

Conditions

Outcome Measures

Primary Outcomes (2)

  • Axial Length

    Ocular biometry was used for measuring the axial length, which is the physical distance between the anterior corneal pole and the retinal structure at the posterior pole.

    Baseline, 1 month, 3 months, 6 months.

  • Cycloplegic Refraction

    Cycloplegic refractive errors were measured with an autorefractor.

    Baseline, 1 month, 3 months, 6 months.

Secondary Outcomes (3)

  • Visual acuity

    Baseline, 1 month, 3 months, 6 months.

  • Anxiety Disorder Screening 7-item Scale

    Baseline, 6 month

  • Strengths and Difficulties Questionnaire

    Baseline, 6 month.

Other Outcomes (1)

  • Fundus Image

    Baseline, 1 month, 3 months, 6 months.

Study Arms (2)

Eye Education Intervention

EXPERIMENTAL

Doctors and nurses will educate parents about eye health in response to their child's myopia progression at baseline, 1 month, 3 months, 6 months.

Behavioral: Eye Education Intervention

Control

EXPERIMENTAL

Parents in the control group will not receive eye health education information from doctors and nurses.

Behavioral: Control

Interventions

Doctors and nurses will educate parents about eye health in response to theirchild's myopia progression at baseline, 1 month, 3 months, 6 months.

Eye Education Intervention
ControlBEHAVIORAL

Parents in the control group will not receive eye health education informationfrom doctors and nurses.

Control

Eligibility Criteria

Age5 Years - 17 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Children aged 5-17;
  • Removing flexible lenses for at least 1 week, flexible astigmatism and hard lenses for at least 3 weeks, orthokeratology lenses for at least 3 months;
  • Best corrected visual acuity of either eye were all ≥ 1.0;
  • The range of myopia in either eye was -15 D ≤ SE ≤ +2.0 D;
  • Astigmatism of either eye less than -5.0 D;
  • Anisometropia ≤ -1.5 D;
  • There was no active ocular inflammatory diseases; no obvious corneal cloud or macula, anormal corneal topography, and no tendency of keratoconus.
  • Intraocular pressure of either eye is of 10 to 21 mmHg;
  • On the basis of full understanding, children and their guardians sign the informed consent;

You may not qualify if:

  • Amblyopia: best corrected visual acuity (BCVA) of either eye less than 1.0 for children over 6 years old;
  • Active ocular inflammatory diseases, such as uveitis and other inflammatory diseases;
  • Secondary myopia, genetic disease or connective tissue- related myopia;
  • Moderate or severe ptosis;
  • Congenital cataract, glaucoma;
  • Other fundus diseases other than myopic related fundus lesions;
  • Intraocular or refractive surgery history;
  • The refractive medium is turbid, and it is impossible to take a clear fundus image; (9)Unable to cooperate with fundus image shooting and other examination;
  • (10)Do not receive cycloplegia or have contraindications; (11)Poor overall condition, unable to follow up for a long time; (12)The subject refuses to participate in the research; (13)Other cases in which the researcher judges that it is not suitable for participation in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Tongren Hospital, Beijing

Beijing, Beijing Municipality, 100730, China

Location

MeSH Terms

Conditions

Health EducationAnxiety Disorders

Condition Hierarchy (Ancestors)

Adherence InterventionsMedication AdherencePatient CompliancePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehaviorMental Disorders

Central Study Contacts

Shi-Ming Li, MD, PHD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

October 21, 2024

First Posted

October 22, 2024

Study Start

October 19, 2024

Primary Completion

April 19, 2025

Study Completion

April 19, 2025

Last Updated

October 22, 2024

Record last verified: 2024-10

Data Sharing

IPD Sharing
Will not share

Locations