Vagus Nerve Stimulation for Reaction Time

NCT07528742 | Recruiting FDA Device

• 1 other identifier: 2026-218
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Non-Invasive Vagus Nerve Stimulation will be provided to the participants using a transcutaneous electrical nerve stimulation (TENS) unit, a routine physical therapy intervention by the faculty researcher who is a licensed physical therapist. The electrodes will be clipped to ear over the vagus nerve distribution area. The parameters will be 30 Hz, 250 us, 5 minutes, at tolerance (no pain). Reaction time will test collected pre and post the stimulation using online reaction time testing platform.

Conditions

Healthy Subjects (HS)

Outcome Measures

Primary Outcomes (1)

• Reaction time

  Reaction time will test collected pre and post the stimulation using online platform. The subjects will press a key when setting a color change in the computer screen.

  Baseline and immediately after the intervention.

Study Arms (1)

vagus nerve stimulation

EXPERIMENTAL

Non-Invasive Vagus Nerve Stimulation will be provided to the participants using a transcutaneous electrical nerve stimulation (TENS) unit, a routine physical therapy intervention by the faculty researcher who is a licensed physical therapist. The electrodes will be clipped to ear over the vagus nerve distribution area. The parameters will be 30 Hz, 250 us, 5 minutes, at tolerance (no pain).

Device: vagus nerve stimulation

Interventions

vagus nerve stimulation DEVICE

Non-Invasive Vagus Nerve Stimulation will be provided to the participants using a transcutaneous electrical nerve stimulation (TENS) unit, a routine physical therapy intervention by the faculty researcher who is a licensed physical therapist. The electrodes will be clipped to ear over the vagus nerve distribution area. The parameters will be 30 Hz, 250 us, 5 minutes, at tolerance (no pain)

vagus nerve stimulation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy participants over the age of 18
• did not receive vagus nerve stimulation previously

You may not qualify if:

• alcohol or drug abuse
• metal in the skull
• implanted cardiac or cranial devices
• Women during 3 trimester of pregnancy

Sponsors & Collaborators

• Youngstown State University: lead

Study Sites (1)

Youngstown State University

Youngstown, Ohio, 44555, United States

RECRUITING

Related Publications (1)

• Camargo L, Gianlorenco AC, Pacheco-Barrios K, Pichardo E, Costa V, Choi H, Song JJ, Fregni F. The effects of non-invasive transcutaneous auricular vagus nerve stimulation on resting-state delta oscillation: a randomized, double-blinded, sham-control trial. Sci Rep. 2025 Oct 3;15(1):34531. doi: 10.1038/s41598-025-17821-5.

  PMID: 41044114 RESULT

MeSH Terms

Interventions

Vagus Nerve Stimulation

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics

Central Study Contacts

Weiqing Ge Ge, DPT, PhD

CONTACT

330-941-2702; wge@ysu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 4, 2026
• First Posted: April 14, 2026
• Study Start: April 6, 2026
• Primary Completion (Estimated): April 5, 2027
• Study Completion (Estimated): April 5, 2027
• Last Updated: April 14, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: One year.

Locations

US (1)