EMG ss AMG In Robotic/Laparoscopic Surgery
PEARL
The Impact Of Electromyography Vs Acceleromyography On The Management Of Neuromuscular Block During Robotic And Laparoscopic Surgery: A Randomized Controlled Trial
1 other identifier
interventional
400
1 country
1
Brief Summary
The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable surgery
Started May 2026
Shorter than P25 for not_applicable surgery
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 30, 2026
CompletedFirst Posted
Study publicly available on registry
April 13, 2026
CompletedStudy Start
First participant enrolled
May 31, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
May 6, 2026
May 1, 2026
7 months
March 30, 2026
May 5, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Cumulative rocuronium dose
Weight- and time-adjusted mean cumulative rocuronium dose between the AMG and EMG groups
Perioperative/Periprocedural
Secondary Outcomes (4)
Mean sugammadex dose
Perioperative/Periprocedural
Number of rocuronium administrations
Perioperative/Periprocedural
Frequency of placing a peripheral nerve stimulator
Perioperative/Periprocedural
Depth of neuromuscular block prior to sugammadex administration
Perioperative/Periprocedural
Study Arms (2)
AMG
EXPERIMENTALThe anesthesia team will manage the level of block based on AMG values
EMG
ACTIVE COMPARATORThe anesthesia team will manage the level of block based on EMG values
Interventions
Eligibility Criteria
You may qualify if:
- Age \> or = 18 years old
- Patients willing to participate and provide an integrated, informed consent
- Patients undergoing elective laparoscopic- or robotic-assisted surgical procedures
You may not qualify if:
- Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
- Patients with systemic neuromuscular diseases such as myasthenia gravis.
- Patients having surgery that would involve prepping the arm into the sterile field.
- Patients with chronic kidney disease (eGFR \<60).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
Johnathan Renew
Mayo Clinic
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 30, 2026
First Posted
April 13, 2026
Study Start
May 31, 2026
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
May 6, 2026
Record last verified: 2026-05
Data Sharing
- IPD Sharing
- Will not share