Correlation Between Preoperative Sleep and Postoperative Brain and Renal Dysfunction

NCT07518992 | Not Yet Recruiting

• 1 other identifier: KY20222231
• Study Type: observational
• Target: 549
• Locations: 0 countries
• Sites: N/A

Brief Summary

To explore the correlation between preoperative sleep parameter clustering and postoperative brain and renal dysfunction.

Conditions

Acute Kidney Injury; Postoperative Delirium

Outcome Measures

Primary Outcomes (3)

• Postoperative delirium

  assessed with 3-minute confusion assessment method (3D-CAM) or confusion assessment method for the ICU (CAM- ICU）

  within 1 week after operation

• Acute kidney injury

  assessed with KDIGO criterion

  within 1 week after operation

• Postoperative delirium combined with acute kidney injury

  both diagnosed as postoperative delirium and acute kidney injury

  within 1 week after operation

Study Arms (1)

Preoperative sleep group

The patient underwent cardiopulmonary coupling sleep monitoring one night before operation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults scheduled for elective cardiac surgery with cardiopulmonary bypass

You may qualify if:

• Aged 18 years or above who were scheduled for elective cardiac surgery with cardiopulmonary bypass

You may not qualify if:

• Patients undergoing congenital heart disease repair surgery or surgeries necessitating deep hypothermic circulatory arrest were excluded.
• Patients with a history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or neurosurgery were also excluded.
• Patients with a preoperative Mini - Mental State Examination (MMSE) score less than 24 , or those unable to communicate due to coma, severe dementia, or language barriers were excluded.

Sponsors & Collaborators

• Xijing Hospital: lead

MeSH Terms

Conditions

Emergence Delirium; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Hailong Dong

  Xijing Hospital

  STUDY CHAIR

Central Study Contacts

Chong Lei

CONTACT

18629011362; crystalleichong@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator, Head of Anesthesia Clinical Research Center, Xijing Hospital

Study Record Dates

• First Submitted: April 1, 2026
• First Posted: April 9, 2026
• Study Start: April 10, 2026
• Primary Completion: April 15, 2026
• Study Completion: April 15, 2026
• Last Updated: April 9, 2026

Record last verified: 2026-04