Drug-induced Kidney Injury Model
Establishment, Evaluation and Treatment Strategy of Drug-induced Kidney Injury Model
1 other identifier
observational
1,500
1 country
1
Brief Summary
To establish the prediction model of renal dysfunction in patients with drug-induced renal injury and study the prognosis of different drug treatments
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 10, 2025
CompletedStudy Start
First participant enrolled
March 10, 2025
CompletedFirst Posted
Study publicly available on registry
April 22, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 30, 2026
April 22, 2025
April 1, 2025
1.8 years
March 10, 2025
April 14, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Model performance metrics assessed by AUC-ROC, accuracy and F1-score using 10-fold cross-validation
The prognosis of renal function was evaluated by measuring creatinine and proteinuria by laboratory tests. Predict outcomes using machine learning methods. And the prediction effect of the prediction model was evaluated by AUC-ROC, F1, accuracy and other indicators.
through study completion, an average of 6 months
Secondary Outcomes (1)
The rate at which creatinine falls
7 days, 1 month, 3 months after treatment
Study Arms (1)
Drug induced acute kidney injury
Patients with acute kidney injury caused by the use of nephrotoxic drugs
Interventions
Observational study, no intervention
Eligibility Criteria
Drug-induced acute kidney injury
You may qualify if:
- Drug-induce acute kidney injury
You may not qualify if:
- Dialysis patients; 2.No baseline creatinine; 3.Obstructive AKI; 4.Clinical data were incomplete.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Zhejiang Provincial People's Hospitallead
- Taizhou Enze Medical Center Groupcollaborator
- Hangzhou Linping District first People's Hospitalcollaborator
- Aksu district first People's Hospitalcollaborator
- Ningbo Yinzhou District Second Hospitalcollaborator
- Wucheng District First People's Hospitalcollaborator
Study Sites (1)
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, 311121, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Target Duration
- 6 Months
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 10, 2025
First Posted
April 22, 2025
Study Start
March 10, 2025
Primary Completion (Estimated)
December 30, 2026
Study Completion (Estimated)
December 30, 2026
Last Updated
April 22, 2025
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will not share
We will publish relevant research papers, patient data is not appropriate for public disclosure