Condylar Offset and Outcomes in Primary Total Knee Arthroplasty

NCT07517614 | Not Yet Recruiting

• 1 other identifier: TKA-OFFSET-2026-01
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to evaluate the effect of posterior condylar offset (PCO) and anterior condylar offset (ACO) changes on functional outcomes after primary total knee arthroplasty (TKA). Standardized imaging and clinical assessment protocols will be used to determine optimal PCO and ACO ranges associated with improved postoperative range of motion, patient-reported outcomes, and reduced anterior knee symptoms.

Conditions

Knee Arthritis Osteoarthritis

Keywords

knee osteoarthiritis; anterior condylar offset; posterior condylar offset

Outcome Measures

Primary Outcomes (1)

• Maximum Knee Flexion

  maximum active knee flexion measured in degrees using a goniometer during clinical examination

  12 months postoperatively

Secondary Outcomes (3)

• Knee Society Score

  3,6,12 months postoperatively

• WOMAC score

  3,6,12 months postoperatively

• Change in Anterior and Posterior Condylar Offset

  preoperative graphy and postoperative 1st day graphy

Study Arms (1)

Primary TKA Cohort

Participants undergoing primary total knee arthtoplasty for knee osteoarthiritis will be prospectively followed. Patients will be evaluated based on postoperative changes in posterior condylar offset and anterior condylar offset.

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients undergoing primary total knee arthroplasty for osteoarthiritis

You may qualify if:

• diagnosis of primary knee osteoarthiritis
• indication of knee arthroplasty
• years
• ability t oprovide informed consent and comply with follow up

You may not qualify if:

• revision knee arthroplasty
• inflammatory arthritis
• severe corona deformity (\>20 varus/valgus)
• previous knee surgery or fracture

Sponsors & Collaborators

• SB Istanbul Education and Research Hospital: lead

Related Publications (2)

• Zhong Y, Deng Z, Gu C, Li M, Kang Y, Liao W, Zhang Z. The Optimal Variation Range of Posterior Condylar Offset Associated with Positive Clinical Outcomes of Primary Total Knee Arthroplasty: A Retrospective Analysis. Orthop Surg. 2024 Nov;16(11):2708-2713. doi: 10.1111/os.14183. Epub 2024 Aug 6.

  PMID: 39107882 BACKGROUND

• Xu W, Huang X, Liu J, Zhang Z, Chen Z, Xia T, Yan B, Xu Y. Sagittal parameters after primary TKA affecting knee joint function: a correlative analysis and predictive model construction. J Orthop Surg Res. 2026 Feb 9;21(1):193. doi: 10.1186/s13018-026-06707-5.

  PMID: 41656286 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 28, 2026
• First Posted: April 8, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): July 1, 2027
• Last Updated: April 8, 2026

Record last verified: 2026-04