Laser vs Lontophoresis in KOA

NCT07666061 | Not Yet Recruiting

• 1 other identifier: KFSIRB200-1047
• Study Type: interventional
• Target: 66
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled trial aims to compare the effectiveness of laser therapy and iontophoresis in patients with knee osteoarthritis. The study will evaluate pain reduction, functional improvement, and knee joint mobility following

Conditions

Knee Arthritis Osteoarthritis

Outcome Measures

Primary Outcomes (3)

• Pain intensity measured using Visual Analogue Scale (VAS)

  Baseline and after 4 weeks of treatment

• Functional disability measured using WOMAC.

  Baseline and after 4 weeks of treatment

• 3. Knee Range of Motion (ROM).

  Baseline and after 4 weeks of treatment

Secondary Outcomes (3)

• Change in physical function assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale

  Baseline (Day 0) and Week 4

• 2. Reduction of joint stiffness.

  Baseline and after 4 weeks of treatment

• Change in daily activities performance assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale

  Baseline (Day 0) and Week 4

Study Arms (3)

Group A:

ACTIVE COMPARATOR

Low-Level Laser Therapy

Device: Low-Level Laser Therapy; Other: Conventional Physical Therapy Only

Group B

ACTIVE COMPARATOR

Iontophoresis

Device: Iontophoresis; Other: Conventional Physical Therapy Only

Group C

ACTIVE COMPARATOR

Conventional Physical Therapy Only

Other: Conventional Physical Therapy Only

Interventions

Iontophoresis DEVICE

Iontophoresis using dexamethasone combined with conventional physical therapy for patients with knee osteoarthritis to reduce pain and improve physical function and knee joint mobility

Group B

Conventional Physical Therapy Only OTHER

Conventional physical therapy program for patients with knee osteoarthritis including therapeutic exercises, stretching, strengthening exercises, and pain relief modalities to improve knee function and mobility.

Group A:; Group B; Group C

Low-Level Laser Therapy DEVICE

Low-level laser therapy combined with conventional physical therapy for patients with knee osteoarthritis to reduce pain and improve functional mobility and knee joint range of motion

Group A:

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \* Age 45-65 years.
• Diagnosed primary knee osteoarthritis (Grade I-II).
• Both genders.
• Ability to follow treatment protocol.

You may not qualify if:

• \* Previous knee surgery.
• Intra-articular injections within last 6 months.
• Pacemaker.
• Skin lesions at treatment area.
• Severe neurological or cardiovascular disorders.

Sponsors & Collaborators

• Kafrelsheikh University: lead

MeSH Terms

Interventions

Low-Level Light Therapy; Iontophoresis

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy; Drug Administration Routes; Drug Therapy; Electrophoresis; Electrochemical Techniques; Investigative Techniques

Study Officials

• hane mohamed hamed, PHD

  professor of orthopedic surgery depaetment of orthopedic surgery faculty of medicine kafrelsheikh university

  STUDY CHAIR

• mahmoud mohamed ewida, PHD

  professor of basic sciences for physical therapy department of basic sciences for physical therapy faculty oh physical therapy kafrelsheikh university

  STUDY CHAIR

Central Study Contacts

abdulaziz fahad alsulaimani, MASTER

CONTACT

966566613748; azoztaif88@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Princpal Investigator

Study Record Dates

• First Submitted: June 12, 2026
• First Posted: June 24, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: June 24, 2026

Record last verified: 2026-06