Muscle Recovery After Total Knee Arthroplasty

NCT06096792 | Completed

• 1 other identifier: K-Bubble TKA
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Total knee arthroplasty (TKA) surgery is a common procedure performed to reduce pain, improve function, and enhance the quality of life in patients with end-stage knee osteoarthritis. As with other knee-related injuries and surgeries, TKA surgery can lead to inhibition of the quadriceps muscle, resulting in a decrease in the muscle's capacity to generate maximum voluntary force. This issue can negatively affect post-injury rehabilitation and function. The long-term persistent neuromuscular muscle inhibition in the quadriceps, one of the most important anti-gravity muscles in our body, leads to muscle atrophy and strength loss, which is more determinant in the development of functional limitations compared to joint range of motion and knee pain. There have been no studies found that assess the quadriceps muscle inhibition occurring during the hospitalization of patients undergoing total knee arthroplasty surgery and examine its impact on post-discharge functional status. The aim of this study is to evaluate the severity of arthrogenic inhibition in the quadriceps muscle of patients following total knee arthroplasty surgery, which is widely practiced in our country and considered the gold standard for the treatment of end-stage knee osteoarthritis. Additionally, the study aims to investigate its impact on post-discharge functional recovery. The data obtained from this study will provide guidance in monitoring patients' early functional recovery post-surgery and in better planning post-surgical rehabilitation. The study will include patients aged 50-75 who have undergone total knee arthroplasty surgery due to knee osteoarthritis. Demographic information such as age, height, weight, and body mass index will be recorded. Pain will be assessed using a visual analog scale, and edema will be measured during hospitalization, at the 2nd and 6th-week follow-up visits. In addition to all the evaluations, functional status will be assessed at the 2nd and 6th-week follow-up visits using the 5-repetition sit-to-stand test, 10-meter walking test, and 2-minute walking tests, as well as knee function evaluated through the WOMAC and KOS-ADLS questionnaires.

Conditions

Knee Arthritis, Osteoarthritis

Keywords

knee arthroplasty; Knee osteoarthritis; muscle inhibition

Outcome Measures

Primary Outcomes (1)

• muscle inhibition

  Quadriceps maximum isometric muscle contraction will be evaluated by measuring the pneumatic pressure change with a pneumatic dynamometer.

  postoperative day-1; postoperative day-2; postoperative day-3; postoperative 2th week and postoperative 6th week

Secondary Outcomes (1)

• Functional recovery

  postoperative 2th week and postoperative 6th week

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent total knee arthroplasty at Hacettepe University faculty of medicine

You may qualify if:

• Age between 50 and 75 years.
• Have undergone unilateral total knee arthroplasty surgery due to osteoarthritis.
• Hemodynamically stable post-surgery.
• Willing to participate in the study.

You may not qualify if:

• Having any neurological or oncological issues.
• Having undergone revision surgery.
• Having a history of cardiovascular surgery.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, Samanpazari, 06100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis; Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Sibel Bozgeyik Bağdatlı, PhD

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: October 18, 2023
• First Posted: October 24, 2023
• Study Start: October 10, 2024
• Primary Completion: March 20, 2025
• Study Completion: September 11, 2025
• Last Updated: March 16, 2026

Record last verified: 2026-03

Locations

TU (1)