Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock

NCT07516236 | Not Yet Recruiting DMC

• 1 other identifier: 1/2026ANET30
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using echocardiography (VTI) and cardiometry. We will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.

Conditions

Sepsis and Septic Shock

Keywords

Diagnostic Accuracy; Dynamic Venous Oxygen Saturation; Fluid Responsiveness; Septic Shock

Outcome Measures

Primary Outcomes (1)

• Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge.

  After 30 mins

Secondary Outcomes (1)

• Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.

  After 30 mins

Interventions

Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge. DEVICE

We will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This single-center, prospective, observational study will be conducted in the Intensive Care Unit (ICU) at Menoufia University Hospitals. Adults spontaneously breathing patients with septic shock who undergo a fluid challenge as a part of their hemodynamic management in the first 24 hours will be eligible for enrollment. Ethical approval will be obtained from the ethics committee at the Menoufia Faculty of Medicine, and the study will follow ethical guidelines and secure approval from the Institutional Review Board (IRB). Written informed consent will be obtained from each participant or their legal surrogate before study inclusion.

You may qualify if:

• Age \> 18 years
• Diagnosis of septic shock according to Sepsis-3 criteria:
• Suspected or confirmed infection o Requirement for vasopressors to maintain MAP \> 65 mmHg o Serum lactate \> 2 mmol/L despite adequate fluid resuscitation

You may not qualify if:

• Pregnancy
• Significant valvular heart disease.
• Atrial fibrillation.
• Inadequate echocardiographic window.
• Ongoing bleeding or contraindication to fluid bolus.

Sponsors & Collaborators

• Menoufia University: lead

Study Sites (1)

Menoufia University

Menouf, Egypt

Location

MeSH Terms

Conditions

Sepsis; Shock, Septic

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 29, 2026
• First Posted: April 7, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: August 18, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)