The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock

NCT06193109 | Completed

• 1 other identifier: Burapha university
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock. Prospective cohort study of adult patients admitted at Burapha university hospital from October 1, 2022 through June 30, 2023 for sepsis and septic shock, who had an echocardiogram within 72 hours after admission for evaluating right ventricular systolic function. Right ventricular systolic dysfunction was defned by the American Society of Echocardiography criteria. Outcomes included 28-day in-hospital mortality, maximal blood lactate, length of intensive care unit(ICU) stay and duration of mechanical ventilation.

Conditions

Sepsis and Septic Shock

Keywords

right ventricular systolic dysfunction

Outcome Measures

Primary Outcomes (1)

• 28 days in-hospital mortality

  28 days in hospital mortality in patients with sepsis or septic shock

  October 1, 2022 and June 30, 2023

Secondary Outcomes (4)

• The prevalence of right ventricular systolic dysfunction

  October 1, 2022 and June 30, 2023

• Blood lactate levels

  October 1, 2022 and June 30, 2023

• Lenght of ICU stay

  October 1, 2022 and June 30, 2023

• Duration of mechanical ventilation

  October 1, 2022 and June 30, 2023

Study Arms (1)

the patients with sepsis or septic shock

devide two groups : (1) They had right ventricular dysfunction and (2) They had no right venticular dysfunction.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A prospective study was conducted at Burapha University Hospital, enrolling admitted patients diagnosed with sepsis and septic shock. Echocardiography was performed on these patients within 72 hours after admission

You may qualify if:

• aged 18 years or older
• diagnosed with sepsis or septic shock according to Sepsis-3 criteria
• received an echocardiogram within 72 hours after admission

You may not qualify if:

• prior diagnosis of pulmonary hypertension,
• cor-pulmonale,
• significant valvular heart disease,
• acute coronary syndrome,
• aortic dissection,
• heart failure
• inability to follow up within 28 days

Sponsors & Collaborators

• Burapha University: lead

Study Sites (1)

Burapha University Hospital

Muang Chonburi, Changwat Chon Buri, 20131, Thailand

Location

Related Publications (1)

• Koowattanatianchai S, Kochaiyapatana P, Eungsuwat N, Rangsrisaeneepitak V, Thammakumpee K, Kaladee K. Significance of Right Ventricular Dysfunction in Predicting Short-Term Survival Among Patients With Sepsis and Septic Shock: A Prognostic Analysis. Crit Care Res Pract. 2025 Mar 14;2025:5511135. doi: 10.1155/ccrp/5511135. eCollection 2025.

  PMID: 40125344 DERIVED

MeSH Terms

Conditions

Sepsis; Shock, Septic

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor Dr.

Study Record Dates

• First Submitted: December 12, 2023
• First Posted: January 5, 2024
• Study Start: October 1, 2022
• Primary Completion: June 30, 2023
• Study Completion: July 30, 2023
• Last Updated: January 5, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: after finishing the research and for 1 year after submission

Locations

TH (1)