Association of Arterio-Venous Oxygen and Carbon Dioxide Gradients With Tissue Hypoperfusion and Mortality in Sepsis

NCT07711405 | Completed

• 1 other identifier: GaziosmanpasaTREH26022025
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

In patients with sepsis who are treated in the intensive care unit under invasive mechanical ventilation, the combined evaluation of ScvO₂ and PcvCO₂ may provide a comprehensive insight into tissue oxygenation and metabolic stress, allowing a more precise hemodynamic assessment in critically ill patients. The aim of this study is to evaluate the monitoring of ScvO₂, PcvCO₂, and EtCO₂ in intensive care patients in order to predict hemodynamic instability, 28-day mortality, and length of ICU stay, as well as to investigate their effects on cardiac output, tissue oxygenation, and hypoperfusion.

Conditions

Intubated ICU Patients; Sepsis and Septic Shock

Keywords

sepsis; central venous carbondiokside; carbondiokside gradient; sepsis mortality; mortality prediction; central venous to arterial carbondiokside

Outcome Measures

Primary Outcomes (1)

• Correlation of the central venous-arterial carbon dioxide difference with 28-day mortality

  The primary outcome of this study is to evaluate the correlation between the central venous-arterial carbon dioxide difference and mortality in patients with sepsis admitted to the intensive care unit. The central venous-arterial carbon dioxide difference will be calculated using paired central venous and arterial blood gas samples obtained at predefined time points (at admission and at 6, 12, and 24 hours). Mortality will be assessed as 28-day all-cause mortality. The correlation between the carbon dioxide difference and mortality will be analyzed to determine its potential value as an indicator of mortality

  from march 2025 to january 2026

Secondary Outcomes (1)

• Predictive accuracy of perfusion parameters and APACHE II score for 28-day mortality

  february 2025 to january 2026

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

İntubated icu patients who diagnosed with sepsis

You may qualify if:

• Adult patients aged 18 years or older
• Diagnosis of sepsis
• Admission to the intensive care unit
• Intubated and receiving invasive mechanical ventilation
• Presence of a central venous catheter

You may not qualify if:

• Patients younger than 18 years
• Patients in whom a central venous catheter cannot be placed
• Patients receiving oxygen therapy via face mask or nasal cannula
• Patients treated with non-invasive mechanical ventilation

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Gaziosmanpasa Training and Research Hospital

Istanbul, Gaziosmanpasa, 34255, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Sepsis; Shock, Septic

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 25, 2025
• First Posted: July 17, 2026
• Study Start: March 1, 2025
• Primary Completion: September 20, 2025
• Study Completion: January 13, 2026
• Last Updated: July 17, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)