Median Nerve Cross-Sectional Area and Body Weight in Carpal Tunnel Syndrome

NCT07508397 | Not Yet Recruiting

• 1 other identifier: 2025-427
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the diagnostic accuracy of ultrasonographic measurements of the median nerve in patients with Carpal Tunnel Syndrome (CTS). While ultrasound is a common diagnostic tool, various physical factors can influence its results. The researchers will investigate how a patient's absolute body weight and Body Mass Index (BMI) affect the size of the median nerve cross-sectional area across different stages of disease severity. The goal is to determine if absolute body weight plays a 'masking' role that could lead to more precise diagnostic interpretations in clinical practice.

Conditions

Carpal Tunnel Syndrome; Entrapment Neuropathies; Median Nerve Compression

Keywords

Ultrasonography; Median Nerve; Cross-Sectional Area; Body Weight; Body Mass Index (BMI); Electromyography; Diagnostic Accuracy; Physical and Rehabilitation Medicine

Outcome Measures

Primary Outcomes (1)

• Median Nerve Cross-Sectional Area (CSA)

  The cross-sectional area of the median nerve measured in square millimeters using high-resolution ultrasonography at the level of the pisiform bone. This measurement is the primary tool for morphological evaluation of the nerve.

  At the time of enrollment (single measurement)

Secondary Outcomes (2)

• Electrophysiological Severity Grading

  At the time of enrollment (single measurement)

• Anthropometric Measurements (Absolute Body Weight and BMI)

  At the time of enrollment

Study Arms (1)

CTS Patient Cohort

Patients aged 18-65 years who were clinically and electrophysiologically diagnosed with idiopathic Carpal Tunnel Syndrome. This single cohort includes patients across all severity stages (mild, moderate, and severe) to evaluate the relationship between median nerve morphology and anthropometric measurements.

Diagnostic Test: High-Resolution Ultrasonography and Electrophysiological Evaluation

Interventions

High-Resolution Ultrasonography and Electrophysiological Evaluation DIAGNOSTIC_TEST

Participants underwent a high-resolution ultrasonographic examination using a high-frequency linear probe to measure the median nerve cross-sectional area (CSA) at the level of the pisiform bone. Subsequently, standardized electrophysiological evaluations (motor distal latency and sensory conduction velocity) were performed to classify CTS severity according to AAEM criteria.

Also known as: Ultrasonography, Nerve Conduction Studies (NCS)

CTS Patient Cohort

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients who were admitted to the Physical and Rehabilitation Medicine (PMR) outpatient clinic with complaints of hand numbness and tingling. The cohort includes individuals from a diverse range of occupational backgrounds and body compositions to evaluate the impact of anthropometric measurements on median nerve morphology.

You may qualify if:

• Patients aged between 18 and 75 years.
• Clinical diagnosis of Carpal Tunnel Syndrome (CTS) based on symptoms (numbness, tingling, nocturnal pain in the median nerve distribution).
• Electrophysiological confirmation of CTS according to the American
• Association of Neuromuscular \& Electrodiagnostic Medicine (AAEM) criteria.
• Ability to provide written informed consent.

You may not qualify if:

• Secondary causes of CTS (e.g., Diabetes Mellitus, Hypothyroidism, Rheumatoid -Arthritis, Chronic Renal Failure).
• Coexisting neurological conditions (e.g., Cervical Radiculopathy,
• Polyneuropathy, Brachial Plexopathy).
• History of previous wrist surgery, trauma, or local corticosteroid injection within the last 6 months.
• Pregnancy or lactation.
• Congenital anatomical variations such as a bifid median nerve or persistent median artery (detected during USG).

Sponsors & Collaborators

• Kayseri City Hospital: lead

Related Publications (2)

• Cartwright MS, Hobson-Webb LD, Boon AJ, Alter KE, Hunt CH, Flores VH, Werner RA, Shook SJ, Thomas TD, Primack SJ, Walker FO; American Association of Neuromuscular and Electrodiagnostic Medicine. Evidence-based guideline: neuromuscular ultrasound for the diagnosis of carpal tunnel syndrome. Muscle Nerve. 2012 Aug;46(2):287-93. doi: 10.1002/mus.23389.

  PMID: 22806381 BACKGROUND

• Jablecki CK, Andary MT, Floeter MK, Miller RG, Quartly CA, Vennix MJ, Wilson JR; American Association of Electrodiagnostic Medicine; American Academy of Neurology; American Academy of Physical Medicine and Rehabilitation. Practice parameter: Electrodiagnostic studies in carpal tunnel syndrome [RETIRED]. Report of the American Association of Electrodiagnostic Medicine, American Academy of Neurology, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2002 Jun 11;58(11):1589-92. doi: 10.1212/wnl.58.11.1589. No abstract available.

  PMID: 12058083 BACKGROUND

MeSH Terms

Conditions

Carpal Tunnel Syndrome; Nerve Compression Syndromes; Body Weight

Interventions

Ultrasonography; Nerve Conduction Studies

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Electrodiagnosis

Central Study Contacts

Abdullah Goktug Yazar, MD

CONTACT

+905309731140; dragyazar@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Abdullah Goktug Yazar

Study Record Dates

• First Submitted: March 24, 2026
• First Posted: April 2, 2026
• Study Start: April 1, 2026
• Primary Completion: July 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: April 2, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share