Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness

NCT07507877 | Recruiting

• 1 other identifier: FMASU-MS 257 / 2026
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid overload.Infraclavicular axillary vein collapsibility index is a substitute for inferior vena cava collapsibility index in assessment for the need of fluid resuscitation in spontaneously breathing sepsis related acute circulatory failure patients.

Conditions

Sepsis

Outcome Measures

Primary Outcomes (1)

• The infraclavicular axillary vein collapsibility index changes in response to fluid challenge.

  The infraclavicular axillary vein collapsibility index changes in response to fluid challenge. A collapsibility index greater than fifty percent in spontaneously breathing patients is commonly associated with a right atrial pressure between zero and five millimeters of mercury.

  Fluid challenge over 10 min time period.

Interventions

Infraclavicular axillary vein collapsibility index OTHER

Assessment of the infraclavicular axillary vein collapsibility index to predict fluid responsiveness in spontaneously breathing patients in sepsis related acute circulatory failure.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* Patients with sepsis must meet at least two or more criteria of systemic inflammatory response syndrome (SIRS). * Spontaneously breathing patients. * Clinical signs of acute circulatory failure.

You may qualify if:

• Adult patients ≥18 years.
• Patients with sepsis must meet at least two or more criteria of systemic inflammatory response syndrome (SIRS).
• Spontaneously breathing patients.
• Clinical signs of acute circulatory failure.

You may not qualify if:

• Patients below the age of 18 years.
• Mechanically ventilated patients

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain-Shams University Hospitals

Cairo, Egypt

RECRUITING

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Ibrahim Mamdouh Esmat

CONTACT

01001241928; ibrahim_mamdouh@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Anesthesia and Intensive Care,Faculty of Medicine, Ain- shams University, Cairo, Egypt.

Study Record Dates

• First Submitted: March 27, 2026
• First Posted: April 2, 2026
• Study Start: April 4, 2026
• Primary Completion (Estimated): November 4, 2026
• Study Completion (Estimated): November 4, 2026
• Last Updated: April 15, 2026

Record last verified: 2026-04

Locations

EG (1)