Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients

NCT06338124 | Recruiting DMC

• 1 other identifier: David Ibrahim
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Sepsis is defined as a dysregulated host response to infection . Despite ongoing efforts, both the incidence and mortality of sepsis have demonstrated limited reductions over the past years,There are several biomarkers that have already been studied for the early diagnosis of sepsis. Some of these markers can be used in risk prediction and monitoring the outcome of sepsis . Some of these markers as procalcitonin and CD14, are costly and not feasible options for low- and middle-income countries . While other biomarkers are feasible and accessible to be evaluated as Triglyceride\\glucose index (TyG) , Relative Distributive Width of red blood corpuscles to albumin ratio (RAR), C-reactive protein,Neutrophile \\Lympocyte ratio and serum lactate levels .

Conditions

Sepsis

Outcome Measures

Primary Outcomes (1)

• Mortality Outcome Measure

  Number of Participants whom will be diagnosed with sepsis and will be admitted in the ICU

  28 days

Study Arms (2)

survivor group

About 50 patients whom will be relifed from the sepsis and will be discharged from the Intensive Care Unit

Diagnostic Test: Triglyceride glucose index

non-survivor group

About 50 patients whom will be died from the sepsis in the Intensive Care Unit

Diagnostic Test: Triglyceride glucose index

Interventions

Triglyceride glucose index DIAGNOSTIC_TEST

To evaluate the role of various laboratory biomarkers ( TyG , RAR , CAR, N\\L ratio, CRP, Serum lactate )in prediction of sepsis outcome.

non-survivor group; survivor group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

To evaluate the role of various laboratory biomarkers ( TyG , RAR , CAR, N\\L ratio, CRP, Serum lactate )in prediction of sepsis outcome

You may qualify if:

• \- patients whom will be diagnosed with sepsis

You may not qualify if:

• patients diagnosed by hematological disease
• patients refused to participate in the research
• patients less than 18 years

Sponsors & Collaborators

• Egymedicalpedia: lead

Study Sites (1)

Assuit University Hospital

Asyut, Egypt

RECRUITING

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Fatema Abu-Bakre, Professor

  Internal medicine, faculty of medicine, Assuit University,Egypt

  STUDY CHAIR

Central Study Contacts

David Ibrahim, MSc Student

CONTACT

+201063734732; davidibrahimfarag@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2024
• First Posted: March 29, 2024
• Study Start: April 1, 2024
• Primary Completion: March 15, 2025
• Study Completion: April 1, 2025
• Last Updated: July 11, 2024

Record last verified: 2024-07

Locations

EG (1)