Pre-implementation Study to Develop Trans-tailored Services for Transgender Persons in Relation to chemsEX

NCT07505875 | Recruiting

• 1 other identifier: IHRI028
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The study is a pre-implementation cross-sectional study exploring chemsex behaviors among transgender persons and gathering perspectives from multiple stakeholders to inform the development of transgender-tailored harm reduction services.

Conditions

Substance Use; Sexually Transmitted Infections (STIs); HIV Prevention

Keywords

Chemsex, Harm reduction

Outcome Measures

Primary Outcomes (3)

• Key themes on chemsex behaviors and service needs

  Qualitative themes identified from semi-structured in-depth interviews, including: * Reasons for engaging in chemsex * Patterns of substance use * Perceived positive and negative impacts * Harm reduction practices * Needs for transgender-tailored services Themes will be identified using thematic analysis.

  At interview (single time point)

• Barriers and facilitators to implementation of transgender-tailored chemsex services

  Barriers and facilitators to implementation identified using the Consolidated Framework for Implementation Research (CFIR) domains based on stakeholder and participant interviews.

  At interview (single time point)

• Chemsex-related behavioral and demographic characteristics

  Descriptive characteristics of participants, including demographic data, substance use patterns, and behavioral risk factors collected via questionnaire.

  At interview (single time point)

Study Arms (3)

Transgender Chemsex Users

Transgender women and transgender men who are current or former chemsex users. Participants will take part in semi-structured in-depth interviews (IDIs) exploring chemsex behaviors, patterns of use, perceived impacts, and needs for transgender-tailored harm reduction services.

Behavioral: Understanding of chemsex patterns, impacts, and service needs among transgender persons

Family Members, Friends, or Partners

Family members, friends, or partners of transgender persons who have not engaged in chemsex. Participants will provide perspectives on the social, behavioral, and relational impacts of chemsex and support needs.

Behavioral: Understanding of chemsex patterns, impacts, and service needs among transgender persons

Stakeholders

Stakeholders including healthcare providers, policy makers, law enforcement officers, counselors, public health professionals, and community leaders involved in care, policy, or regulation related to chemsex. Participants will be interviewed to identify system-level facilitators and barriers to implementation of services.

Behavioral: Understanding of chemsex patterns, impacts, and service needs among transgender persons

Interventions

Understanding of chemsex patterns, impacts, and service needs among transgender persons BEHAVIORAL

: During study period (single visit within \~12 months study duration)

Family Members, Friends, or Partners; Stakeholders; Transgender Chemsex Users

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: transgender population focus
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

G1: Transgender chemsex users * Transgender women or transgender men * Current or former chemsex users G2: Family / partners * Family members, friends, or partners of transgender persons * Never engaged in chemsex * Able to communicate in Thai G3: Stakeholders * Healthcare providers, policymakers, law enforcement, counselors, community leaders * Involved in chemsex-related care/policy * Able to communicate in Thai

You may qualify if:

• Age ≥18 years
• Able to communicate in Thai
• Provide informed consent

You may not qualify if:

• Unable to participate in in-depth interview (IDI) (online or onsite)

Sponsors & Collaborators

• amfAR, The Foundation for AIDS Research: collaborator
• Institute of HIV Research and Innovation Foundation, Thailand: lead

Study Sites (1)

Tangerine Clinic, Institute of HIV Research and Innovation

Pathum Wan, Bangkok, 10330, Thailand

RECRUITING

MeSH Terms

Conditions

Substance-Related Disorders; Sexually Transmitted Diseases; Chemsex; Harm Reduction

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Communicable Diseases; Infections; Genital Diseases; Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Sexual Behavior; Behavior

Study Officials

• Nittaya Phanuphak, MD,PhD.

  Institute of HIV Research and Innovation (IHRI)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nittaya Phanuphak, MD,PhD.

CONTACT

6681 825 3544; nittaya.p@ihri.org

Rena Janamnuaysook, MBA

CONTACT

662 160 5371; rena.j@ihri.org

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2026
• First Posted: April 1, 2026
• Study Start: May 1, 2024
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): May 1, 2027
• Last Updated: April 1, 2026

Record last verified: 2026-03

Locations

TH (1)