How Stroke Affects Leg Muscles When Walking

NCT07504627 | Completed

• 1 other identifier: 87RI25-0051_MCOACT
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Stroke is the leading cause of acquired disability in France and the third leading cause worldwide. This research will :

• Test how reliable current medical methods are for measuring muscle activity.
• Improve understanding of how leg muscles work in people after a stroke.
• Identify early signs that predict good or poor recovery of walking ability.
• Shed light on the mechanisms that support walking recovery after a stroke. In the long run, these results will help improve rehabilitation programs, make care more personalized, and support patients in regaining independence.

Conditions

Stroke; Physical Inactivity; Spasticity, Muscle; Walking, Difficulty

Keywords

Stroke; Physical Inactivity; Spasticity, Muscle; Walking, Difficulty

Outcome Measures

Primary Outcomes (1)

• Identification of specific muscle activation patterns during walking in individuals with stroke

  Difference in temporal and amplitude indices of muscle activation depending on the severity of post-stroke sequelae

  Day 1

Secondary Outcomes (2)

• Identification of factors associated with good and poor prognoses for walking recovery after stroke

  Day 1

• Description of the metrological qualities of methods for measuring muscle activation as practiced in routine care

  Day 1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individual diagnosed with stroke who underwent an instrumented gait analysis with muscle activation measurements

* Patients with a confirmed diagnosis of stroke ; * Patients who have undergone an instrumented gait analysis, including measurements of muscle activation (e.g., electromyography).

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University Hospital, Limoges: lead

Study Sites (1)

Chu de Limoges

Limoges, 87000, France

Location

Related Publications (7)

• Chow JW, Yablon SA, Stokic DS. Coactivation of ankle muscles during stance phase of gait in patients with lower limb hypertonia after acquired brain injury. Clin Neurophysiol. 2012 Aug;123(8):1599-605. doi: 10.1016/j.clinph.2012.01.006. Epub 2012 Feb 9.

  PMID: 22325644 BACKGROUND

• Collin C, Wade D. Assessing motor impairment after stroke: a pilot reliability study. J Neurol Neurosurg Psychiatry. 1990 Jul;53(7):576-9. doi: 10.1136/jnnp.53.7.576.

  PMID: 2391521 BACKGROUND

• Compagnat M, Daviet JC, Batcho C, Vuillerme N, Salle JY, David R, Mandigout S. Oxygen Cost During Walking in Individuals With Stroke: Hemiparesis Versus Cerebellar Ataxia. Neurorehabil Neural Repair. 2020 Apr;34(4):289-298. doi: 10.1177/1545968320907076. Epub 2020 Feb 24.

  PMID: 32089099 BACKGROUND

• Daviet, J. C., Compagnat, M., Bernikier, D., Salle, J.-Y. . Réadaptation après accident vasculaire cérébral : Retour et maintien à domicile, vie quotidienne. Bulletin de l'Académie Nationale de Médecine. 2022; 206(5), 616-622.

  BACKGROUND

• Demeurisse G, Demol O, Robaye E. Motor evaluation in vascular hemiplegia. Eur Neurol. 1980;19(6):382-9. doi: 10.1159/000115178.

  PMID: 7439211 BACKGROUND

• Den Otter AR, Geurts AC, Mulder T, Duysens J. Gait recovery is not associated with changes in the temporal patterning of muscle activity during treadmill walking in patients with post-stroke hemiparesis. Clin Neurophysiol. 2006 Jan;117(1):4-15. doi: 10.1016/j.clinph.2005.08.014. Epub 2005 Dec 5.

  PMID: 16337186 BACKGROUND

• Detrembleur C, Dierick F, Stoquart G, Chantraine F, Lejeune T. Energy cost, mechanical work, and efficiency of hemiparetic walking. Gait Posture. 2003 Oct;18(2):47-55. doi: 10.1016/s0966-6362(02)00193-5.

  PMID: 14654207 BACKGROUND

MeSH Terms

Conditions

Stroke; Sedentary Behavior; Muscle Spasticity; Mobility Limitation

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Behavior; Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Maxence MC COMPAGNAT, Pr

  University Hospital, Limoges

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 25, 2026
• First Posted: April 1, 2026
• Study Start: August 19, 2025
• Primary Completion: August 19, 2025
• Study Completion: August 19, 2025
• Last Updated: April 1, 2026

Record last verified: 2025-08

Locations

FR (1)