The Effect of Magnesium on Post-spinal Headaches

NCT07502482 | Active Not Recruiting

• 1 other identifier: MG-260326
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia

Conditions

Post-spinal Headache

Outcome Measures

Primary Outcomes (1)

• Incidence of post-spinal headache

  the number of people who develop a headache following spinal anaesthesia

  1. day

Study Arms (2)

administered intravenous magnesium

Other: Magnesium

without intravenous magnesium

Other: Magnesium

Interventions

Magnesium OTHER

Post-spinal headache in patients receiving magnesium

administered intravenous magnesium; without intravenous magnesium

Eligibility Criteria

• Age: 18 Years - 45 Years
• Gender Eligibility Details: pregnant
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

In this study, which is designed as a retrospective cohort study, the records of all patients who underwent caesarean section under spinal anaesthesia at our hospital between 1 January 2025 and 31 December 2025 and who met the inclusion criteria will be reviewed.

You may qualify if:

• Patients aged 18-45
• Patients who underwent spinal anaesthesia for elective caesarean section
• Patients with an ASA physical status score of I-III
• Patients in whom a 25G or 27G pencil-point needle was used for spinal anaesthesia
• Patients with complete medical records

You may not qualify if:

• Patients undergoing emergency surgery
• Patients with a history of chronic headaches
• Patients who have undergone unsuccessful spinal anaesthesia or multiple attempts
• Patients who have undergone combined spinal-epidural anaesthesia
• Patients with a contraindication to magnesium sulphate
• Patients with insufficient medical records

Sponsors & Collaborators

• Haseki Training and Research Hospital: lead

Study Sites (1)

Haseki Training and Research Hospital

Istanbul, Sultangazi, Turkey (Türkiye)

Location

Related Publications (2)

• Uppal V, Russell R, Sondekoppam R, Ansari J, Baber Z, Chen Y, DelPizzo K, Dirzu DS, Kalagara H, Kissoon NR, Kranz PG, Leffert L, Lim G, Lobo CA, Lucas DN, Moka E, Rodriguez SE, Sehmbi H, Vallejo MC, Volk T, Narouze S. Consensus Practice Guidelines on Postdural Puncture Headache From a Multisociety, International Working Group: A Summary Report. JAMA Netw Open. 2023 Aug 1;6(8):e2325387. doi: 10.1001/jamanetworkopen.2023.25387.

  PMID: 37581893 RESULT

• Alatni RI, Alsamani R, Alqefari A. Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. Cureus. 2024 Jan 15;16(1):e52330. doi: 10.7759/cureus.52330. eCollection 2024 Jan.

  PMID: 38361721 RESULT

MeSH Terms

Conditions

Post-Dural Puncture Headache

Interventions

Magnesium

Condition Hierarchy (Ancestors)

Headache Disorders, Secondary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Metals, Alkaline Earth; Elements; Inorganic Chemicals; Metals, Light; Metals

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: March 26, 2026
• First Posted: March 31, 2026
• Study Start: April 1, 2026
• Primary Completion: May 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: July 7, 2026

Record last verified: 2026-07

Locations

TU (1)