NCT00000610

Brief Summary

To determine whether early intravenous magnesium treatment of patients with suspected acute myocardial infarction reduces mortality.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Apr 1998

Typical duration for phase_3 cardiovascular-diseases

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1998

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

October 27, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 28, 1999

Completed
4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2003

Completed
Last Updated

April 14, 2016

Status Verified

March 1, 2005

First QC Date

October 27, 1999

Last Update Submit

April 13, 2016

Conditions

Cardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial InfarctionMyocardial Ischemia

Interventions

magnesiumDRUG

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Patients with suspected acute myocardial infarction (presenting with ST elevation on the electrocardiogram) and who were at (relatively) high risk for mortality.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (4)

  • MAGIC Steering Committee. Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction. Am Heart J. 2000 Jan;139(1 Pt 1):10-4.

    PMID: 10618556BACKGROUND

  • Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet. 2002 Oct 19;360(9341):1189-96. doi: 10.1016/s0140-6736(02)11278-5.

    PMID: 12401244BACKGROUND

  • Domanski M, Antman EM, McKinlay S, Varshavsky S, Platonov P, Assmann SF, Norman J. Geographic variability in patient characteristics, treatment and outcome in an International Trial of Magnesium in acute myocardial infarction. Control Clin Trials. 2004 Dec;25(6):553-62. doi: 10.1016/j.cct.2004.08.005.

    PMID: 15588742BACKGROUND

  • Cooper HA, Domanski MJ, Rosenberg Y, Norman J, Scott JH, Assmann SF, McKinlay SM, Hochman JS, Antman EM; Magnesium in Coronaries trial investigators. Acute ST-segment elevation myocardial infarction and prior stroke: an analysis from the Magnesium in Coronaries (MAGIC) trial. Am Heart J. 2004 Dec;148(6):1012-9. doi: 10.1016/j.ahj.2004.02.017.

    PMID: 15632887BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial InfarctionMyocardial Ischemia

Interventions

Magnesium

Condition Hierarchy (Ancestors)

Vascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Intervention Hierarchy (Ancestors)

Metals, Alkaline EarthElementsInorganic ChemicalsMetals, LightMetals

Study Officials

  • Sonja McKinlay

    New England Research Institutes, Inc.

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Purpose
TREATMENT
Sponsor Type
NIH

Study Record Dates

First Submitted

October 27, 1999

First Posted

October 28, 1999

Study Start

April 1, 1998

Study Completion

November 1, 2003

Last Updated

April 14, 2016

Record last verified: 2005-03