Serum Magnesium Level in Type 2 Diabetes Mellitus

NCT06059833 | Unknown

• 1 other identifier: Soh-Med-23-07-14MS
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. It may be due to impaired insulin secretion, resistance to peripheral actions of insulin, or both . Chronic hyperglycemia in synergy with the other metabolic aberrations in patients with diabetes mellitus can cause damage to various organ systems, leading to the development of disabling and life-threatening health complications, most prominent of which are microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular complications leading to a 2-fold to 4-fold increased risk of cardiovascular diseases Mg2+ deficiency is usually identified by the measurement of serum Mg2+ concentration. Hypomagnesemia is defined by a serum Mg2+ concentration \< 0.75 mmol/L, but a deficiency due to low dietary intake in otherwise healthy people is uncommon. Although overt signs of clinical Mg2+ deficiency are not routinely recognized in the healthy population, relatively low Mg2+ intake and/or Mg2+ status have been shown to be associated with chronic diseases, including cardiovascular disease, T2DM, osteoporosis, pulmonary disease, depression, migraine headaches, inflammation, and cancer

Conditions

Diabetes Mellitus

Outcome Measures

Primary Outcomes (1)

• magnesium perecentage

  evaluate serum Mg level in type 2 DM patients.

  1 year

Study Arms (2)

cases group

Diagnostic Test: Magnesium

control group

Diagnostic Test: Magnesium

Interventions

Magnesium DIAGNOSTIC_TEST

The aim of the study is to evaluate serum Mg level in type 2 DM patients.

cases group; control group

Eligibility Criteria

• Age: 30 Years+
• Sex: female
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Type 2 Diabetes Mellitus according to WHO criteria.

You may qualify if:

• Type 2 Diabetes Mellitus according to WHO criteria.

You may not qualify if:

• Renal failure patients.
• Type I DM patients.
• Acute pancreatitis.
• Hyperthyroidism.
• Hyperparathyroidism.
• Malignancies.
• Patients on loop/thiazide diuretics.
• Patients on Mg supplement.
• Patients on Mg containing antacids.
• Any other conditions causing low Mg levels were excluded from the study.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university Hospital

Sohag, Egypt

Location

Related Publications (4)

• Zheng L, Zhu X, Yang K, Zhu M, Farooqi AA, Kang D, Sun M, Xu Y, Lin X, Feng Y, Liang F, Zhang F, Linhardt RJ. Correction: Zheng, L., et al. PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways. Polymers 2018, 10, 1043. Polymers (Basel). 2021 Jan 5;13(1):166. doi: 10.3390/polym13010166.

  PMID: 33466568 BACKGROUND

• Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martin C. Pathophysiology of Type 2 Diabetes Mellitus. Int J Mol Sci. 2020 Aug 30;21(17):6275. doi: 10.3390/ijms21176275.

  PMID: 32872570 BACKGROUND

• Piuri G, Zocchi M, Della Porta M, Ficara V, Manoni M, Zuccotti GV, Pinotti L, Maier JA, Cazzola R. Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients. 2021 Jan 22;13(2):320. doi: 10.3390/nu13020320.

  PMID: 33499378 BACKGROUND

• Feng J, Wang H, Jing Z, Wang Y, Cheng Y, Wang W, Sun W. Role of Magnesium in Type 2 Diabetes Mellitus. Biol Trace Elem Res. 2020 Jul;196(1):74-85. doi: 10.1007/s12011-019-01922-0. Epub 2019 Nov 11.

  PMID: 31713111 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Central Study Contacts

hassnaa M kamel, resident

CONTACT

01009700227; hasnaamohamed@med.sohage.edu.eg

Elham o Hamd, professor

CONTACT

01063090309

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident-clinical pathology department-sohag hospital university

Study Record Dates

• First Submitted: September 22, 2023
• First Posted: September 29, 2023
• Study Start: September 1, 2023
• Primary Completion: September 1, 2024
• Study Completion: September 1, 2024
• Last Updated: September 29, 2023

Record last verified: 2023-09

Locations

EG (1)