Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome

NCT07498998 | Not Yet Recruiting

• 1 other identifier: 36264MS877/3/25
• Study Type: interventional
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the efficacy and outcomes of perineural injection with 5% dextrose, local ozone and glucocorticoid injection in the management of carpal tunnel syndrome.

Conditions

Carpal Tunnel Syndrome (CTS); Glucocorticoid; Pain; Dextrose

Keywords

glucocorticoid; Ozone; 5% dextrose; carpal tunnel syndrome

Outcome Measures

Primary Outcomes (1)

• median nerve distal motor latency

  3 months

Secondary Outcomes (1)

• Evaluation of analgesic efficacy via assessment of Visual Analog Scale

  At 1 and 3 months.

Study Arms (3)

Group 1

EXPERIMENTAL

Perineural injection with 5% dextrose

Drug: Perineural injection with 5% dextrose (D5W).

Group 2

EXPERIMENTAL

Local ozone injection

Drug: Local ozone injection

Group 3

EXPERIMENTAL

Local glucocorticoid injection

Drug: Local glucocorticoid injection (dexamethasone).

Interventions

Perineural injection with 5% dextrose (D5W). DRUG

Group 1: Perineural injection with 5% dextrose (D5W).

Group 1

Local ozone injection DRUG

Group 2: Local ozone injection

Group 2

Local glucocorticoid injection (dexamethasone). DRUG

Group 3: Local glucocorticoid injection (dexamethasone).

Group 3

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18-65 years with a clinical diagnosis of mild to moderate Carpal Tunnel Syndrome .
• Clinical diagnosis of mild to moderate Carpal Tunnel Syndrome , as classified by Bland neurophysiological classification scale: Mild Carpal Tunnel Syndrome : Slow Distal Sensory Latency(≥3.6 ms), Normal Distal Motor Latency(\< 4.5 ms)
• Moderate Carpal Tunnel Syndrome : Slow Distal Sensory Latency (≥ 3.6 ms), Slow Distal Motor Latency (4.5 - 6.4 ms)
• Failure to respond to conservative treatments (e.g., splinting, activity modification, or oral medications) for at least 6 weeks.

You may not qualify if:

• Patient refusal.
• Severe Carpal Tunnel Syndrome requiring surgical intervention, as defined by the Bland neurophysiological classification scale: Severe Carpal Tunnel Syndrome: Absent Distal Sensory Latency and Slow Distal Motor Latency (4.5 - 6.4 ms)
• Previous corticosteroid injection for Carpal Tunnel Syndrome within the last 6 months.
• History of wrist trauma, surgery or anatomical abnormalities.
• Systemic conditions such as diabetes mellitus, thyroid dysfunction or rheumatoid arthritis.
• Pregnancy or lactation.
• Contraindications to any of the study interventions (e.g., allergy to glucocorticoids or ozone).
• Infection at wrist.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, Egypt

Location

MeSH Terms

Conditions

Carpal Tunnel Syndrome; Pain

Interventions

Glucose; Dexamethasone

Condition Hierarchy (Ancestors)

Median Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Nerve Compression Syndromes; Cumulative Trauma Disorders; Sprains and Strains; Wounds and Injuries; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates; Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated

Central Study Contacts

Tasnim Ayad, Resident

CONTACT

+20 10 12537424; tasnimayad15@gmail.com

Tasnim Ayad, Resident

CONTACT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: February 6, 2026
• First Posted: March 27, 2026
• Study Start: July 30, 2026
• Primary Completion (Estimated): August 30, 2026
• Study Completion (Estimated): August 30, 2026
• Last Updated: March 27, 2026

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

EG (1)