3-Needle vs 5-Needle of Genicular Nerve Block on Pain and Quality of Life in Knee Osteoarthritis

NCT07853170 | Not Yet Recruiting

• 1 other identifier: 36265PR192/8/26
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the 3-needle and 5-needle of genicular nerve block on pain and quality of life in Knee osteoarthritis (KOA).

Conditions

5-Needle; Quality of Life; 3-Needle; Genicular Nerve Block; Pain; Knee Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Degree of pain

  Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable").

  6 months postoperatively

Secondary Outcomes (3)

• Measurement of Quality of life

  6 months postoperatively

• Patients' opioid medication use

  6 months after treatment

• Degree of patient satisfaction

  6 months postoperatively

Study Arms (2)

Group I (3-nerve-targeted group)

EXPERIMENTAL

Patients will receive 3-nerve protocol.

Other: 3-nerve-targeted group

Group II (5-nerve-targeted group)

EXPERIMENTAL

Patients will receive 5-nerve protocol.

Other: 5-nerve-targeted group

Interventions

3-nerve-targeted group OTHER

Patients will receive 3-nerve protocol.

Group I (3-nerve-targeted group)

5-nerve-targeted group OTHER

Patients will receive 5-nerve protocol.

Group II (5-nerve-targeted group)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years.
• Both sexes.
• Patients with unilateral chronic knee pain for more than 3 months.
• Patients received conservative treatment for at least 3 months.
• Diagnosed Knee osteoarthritis (KOA) according to the American College of Rheumatology (ACR) criteria, and grade greater than or equal to Kellgren-Lawrence grade 2.

You may not qualify if:

• Chronic knee pain is due to causes other than KOA, such as connective tissue diseases, lumbar radicular neuropathy (spondylolisthesis, spinal stenosis), or sciatic pain.
• Knee effusion.
• Neuro/psychiatric disorders.
• History of intra-articular injection in the prior 3 months.
• Prior knee surgery.
• Active systemic or local knee infections; anticoagulant use.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Related Publications (1)

• Geng R, Li J, Yu C, Zhang C, Chen F, Chen J, Ni H, Wang J, Kang K, Wei Z, Xu Y, Jin T. Knee osteoarthritis: Current status and research progress in treatment (Review). Exp Ther Med. 2023 Aug 25;26(4):481. doi: 10.3892/etm.2023.12180. eCollection 2023 Oct.

  PMID: 37745043 RESULT

MeSH Terms

Conditions

Pain; Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Mohammed S Elsharkawy, MD

CONTACT

00201148207870; mselsharkawy@med.tanta.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: September 27, 2026
• First Posted: October 1, 2026
• Study Start (Estimated): October 15, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: October 1, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)