Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers

NCT07498075 | Not Yet Recruiting

• 1 other identifier: nigeria_hpv_857299
• Study Type: interventional
• Target: 3,340
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study evaluates whether different types of digital health communication can increase parents' intention to vaccinate their daughters against human papillomavirus (HPV) in Nigeria. HPV vaccination is recommended for girls aged 9-14 years and helps prevent cervical cancer, yet vaccination rates remain low. Parents of eligible, unvaccinated girls will be randomly assigned to receive one of several types of digital content delivered online. These include: (1) a short chatbot conversation based on motivational interviewing principles, (2) an interactive game designed to help parents recognize and resist common forms of vaccine misinformation, (3) a set of short edutainment videos about HPV vaccination, (4) standard informational infographics about HPV vaccination from a national public health agency, or (5) unrelated health content about menstruation. The main outcome is parents' self-reported intention to vaccinate their daughter against HPV, measured immediately and one week after exposure to the assigned content. Additional outcomes include HPV-related knowledge, perceptions of vaccine safety, willingness to recommend the vaccine to others, and self-reported vaccine uptake at 1-week and 6 month follow-up. The results will help inform scalable communication strategies to improve HPV vaccination uptake in low- and middle-income settings.

Conditions

HPV; HPV Vaccine

Keywords

HPV; HPV Vaccine; Chatbots; Misinformation; Pre-Bunking

Outcome Measures

Primary Outcomes (2)

• HPV Vaccination Intention (1-Week Post-Intervention)

  Parent's self-reported intention to vaccinate their selected daughter (aged 9-14 years) against HPV, measured on a 10-point numeric scale, where higher values indicate greater intention to vaccinate. If a participant has more than one eligible daughter, one daughter is randomly selected for all outcome questions.

  1 week after exposure to the assigned intervention content

• HPV Vaccination Intention (Immediately Post-Intervention)

  Parent's self-reported intention to vaccinate their selected daughter against HPV, measured on a 10-point numeric scale.

  Immediately Post-Intervention

Secondary Outcomes (12)

• HPV Vaccination Intention (6 months post-intervention)

  6 months post-intervention

• Self-Reported HPV Vaccine Uptake

  6 months post-intervention

• Perceived Safety of the HPV Vaccine

  1 week post-intervention, 6 months post-intervention

• Likelihood of Recommending the HPV Vaccine to Other Parents

  1 week post-intervention, 6 months post-intervention

• Self-Reported Knowledge of the HPV Vaccine

  1 week post-intervention, 6 months post-intervention

Other Outcomes (1)

• Engagement With Assigned Intervention Content

  During intervention exposure

Study Arms (5)

Chatbot counseling arm

EXPERIMENTAL

A brief motivational-interviewing-style chatbot dialogue adapted from WHO vaccination counseling guidance

Behavioral: Chatbot counseling

Misinformation-resistance pre-bunking inoculation arm

EXPERIMENTAL

A short interactive game (approximately 3-5 minutes) designed to build resistance to HPV vaccine misinformation

Behavioral: Misinformation-resistance pre-bunking inoculation

Short edutainment arm

EXPERIMENTAL

5-6 brief edutainment videos (total viewing time approximately 10-15 minutes) providing HPV vaccine information tailored to the Nigerian context

Behavioral: Short edutainment

Standard infographic control arm

ACTIVE COMPARATOR

Existing infographics on HPV vaccination from Nigeria's National Primary Health Care Development Agency (NPHCDA)

Behavioral: Standard infographic control

Unrelated content control arm

NO INTERVENTION

Series of infographics on menstruation from Nigeria's Menstrual Health Advocacy Consortium

Interventions

Chatbot counseling BEHAVIORAL

A brief motivational-interviewing-style chatbot dialogue adapted from WHO vaccination counseling guidance

Chatbot counseling arm

Misinformation-resistance pre-bunking inoculation BEHAVIORAL

A short interactive game (approximately 3-5 minutes) designed to build resistance to HPV vaccine misinformation

Misinformation-resistance pre-bunking inoculation arm

Short edutainment BEHAVIORAL

5-6 brief edutainment videos (total viewing time approximately 10-15 minutes) providing HPV vaccine information tailored to the Nigerian context

Short edutainment arm

Standard infographic control BEHAVIORAL

Existing infographics on HPV vaccination from Nigeria's National Primary Health Care Development Agency (NPHCDA)

Standard infographic control arm

Eligibility Criteria

• Age: 27 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Parent or primary caregiver of at least one girl aged 9-14 years
• Parent states "no" or "unsure" to question asking if eligible daughter has received any doses of the HPV vaccine
• Provides informed consent to participate

You may not qualify if:

• Parent or caregiver of a girl who has already received one or more doses of the HPV vaccine
• Does not meet age eligibility criteria for an eligible daughter
• Fails Attention Checks

Sponsors & Collaborators

• University of Pennsylvania: lead
• World Bank Group: collaborator

MeSH Terms

Conditions

Communication

Condition Hierarchy (Ancestors)

Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 23, 2026
• First Posted: March 27, 2026
• Study Start: May 18, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share