Impact of a Mock-up Fact-checking Extension on HPV Vaccine Misinformation: A Survey Experiment

NCT06405048 | Not Yet Recruiting

• 1 other identifier: Fact-checking Extension
• Study Type: interventional
• Target: 1,200
• Locations: 1 country
• Sites: 2

Brief Summary

The primary objective of this survey experiment study is to measure the impact of a mock-up Chinese fact-checking extension on the ability to dispel HPV and HPV vaccine-related misinformation among parents of middle school girls in China.

Conditions

HPV Vaccine

Keywords

HPV vaccine; knowledge; misinformation; vaccine confidence; fact-checking extension

Outcome Measures

Primary Outcomes (1)

• Ability to debunk misinformation

  This outcome measures participants' ability to debunk misinformation about the HPV or HPV vaccine. Total debunking scores range from 0 to 10, with higher scores reflecting better debunking skills.

  Day 1, in a single survey

Secondary Outcomes (4)

• HPV vaccination intention

  Day 1, in a single survey

• HPV vaccine confidence

  Day 1, in a single survey

• Tool acceptance

  Day 1, in a single survey

• User experience of mock-up fact-checking extension

  Day 1, in a single survey

Study Arms (2)

Mock-up fact-checking extension intervention group

EXPERIMENTAL

Intervention group participants will engage with three modules: In Module 1, participants will examine six Weibo post screenshots, each featuring a mock-up of a Chinese fact-checking extension. Participants in the intervention group will assess a statement linked to the content of each post, which aligns with predefined HPV vaccine knowledge from section (b). Their response options will be: 1) Correct, 2) Incorrect, or 3) I don't know, taking into account both the post and the extension's feedback. In the module 2, participants will review four additional Weibo post screenshots, two of which include false information. Responses will follow the same format used in Module 1. In Module 3, participants will choose whether to view Weibo post screenshots with the fact-checking extension enabled or disabled. If they choose "Yes", the screenshot will be displayed with the extension; if "No", it will be shown without the extension.

Other: Mobile Weibo post screenshot with mock-up Chinese fact-checking extension

Control group

NO INTERVENTION

Control group participants will participate in three modules: In Modules 1 and 2, they will review six and four Weibo post screenshots, respectively, without the mock-up Chinese fact-checking extension. Participants will evaluate statements linked to the content of each post, aligning with predefined HPV vaccine knowledge from section (b). Their response options will be: 1) Correct, 2) Incorrect, or 3) I don't know, based solely on the content of the posts. In Module 3, participants will choose whether to view Weibo post screenshots with the fact-checking extension enabled or disabled. If they choose "Yes", the screenshot will be displayed with the extension; if "No", it will be shown without the extension.

Interventions

Mobile Weibo post screenshot with mock-up Chinese fact-checking extension OTHER

The intervention in this survey experiment involves mobile Weibo post screenshots equipped with a mock-up Chinese fact-checking browser extension. All screenshots are based on actual Weibo posts. The fact-checking content is generated by a Large Language Model (LLM), tailored to relevant knowledge and prompts, and subsequently validated by experts. The Weibo posts cover a range of popular topics known to contain misinformation, including infertility, safety, vaccine ingredients, high-risk cervical cancer types, regular check-ups, transmission routes, and others.

Mock-up fact-checking extension intervention group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants must be parents or legal guardians of female students currently enrolled in participating middle school.
• The parent's or guardian's female middle school student must not have received the HPV vaccine, must not have an HPV vaccination appointment scheduled, and must not have any contraindications to receiving the HPV vaccine.
• Participants must be free of mental health disorders or visual/reading disabilities that could prevent their full participation in and completion of the intervention activities.
• Participants must have provided informed consent and expressed a willingness to actively participate throughout the study.

Sponsors & Collaborators

• Fudan University: lead
• The University of Hong Kong: collaborator

Study Sites (2)

Chizhou Health Center for Disease Control and Prevention

Chizhou, Anhui, 247100, China

Location

Jiading District Center for Disease Control and Prevention

Shanghai, Shanghai Municipality, 201800, China

Location

Related Publications (17)

• Lee KY, Dabak SV, Kong VH, Park M, Kwok SLL, Silzle M, Rachatan C, Cook A, Passanante A, Pertwee E, Wu Z, Elkin JA, Larson HJ, Lau EHY, Leung K, Wu JT, Lin L. Effectiveness of chatbots on COVID vaccine confidence and acceptance in Thailand, Hong Kong, and Singapore. NPJ Digit Med. 2023 May 25;6(1):96. doi: 10.1038/s41746-023-00843-6.

  PMID: 37231110 BACKGROUND

• Huang S, Yang J, Fong S, Zhao Q. Artificial intelligence in the diagnosis of COVID-19: challenges and perspectives. Int J Biol Sci. 2021 Apr 10;17(6):1581-1587. doi: 10.7150/ijbs.58855. eCollection 2021.

  PMID: 33907522 BACKGROUND

• Scherer LD, McPhetres J, Pennycook G, Kempe A, Allen LA, Knoepke CE, Tate CE, Matlock DD. Who is susceptible to online health misinformation? A test of four psychosocial hypotheses. Health Psychol. 2021 Apr;40(4):274-284. doi: 10.1037/hea0000978. Epub 2021 Mar 1.

  PMID: 33646806 BACKGROUND

• Bin Naeem S, Kamel Boulos MN. COVID-19 Misinformation Online and Health Literacy: A Brief Overview. Int J Environ Res Public Health. 2021 Jul 30;18(15):8091. doi: 10.3390/ijerph18158091.

  PMID: 34360384 BACKGROUND

• Southwick L, Guntuku SC, Klinger EV, Seltzer E, McCalpin HJ, Merchant RM. Characterizing COVID-19 Content Posted to TikTok: Public Sentiment and Response During the First Phase of the COVID-19 Pandemic. J Adolesc Health. 2021 Aug;69(2):234-241. doi: 10.1016/j.jadohealth.2021.05.010. Epub 2021 Jun 22.

  PMID: 34167883 BACKGROUND

• Tangcharoensathien V, Calleja N, Nguyen T, Purnat T, D'Agostino M, Garcia-Saiso S, Landry M, Rashidian A, Hamilton C, AbdAllah A, Ghiga I, Hill A, Hougendobler D, van Andel J, Nunn M, Brooks I, Sacco PL, De Domenico M, Mai P, Gruzd A, Alaphilippe A, Briand S. Framework for Managing the COVID-19 Infodemic: Methods and Results of an Online, Crowdsourced WHO Technical Consultation. J Med Internet Res. 2020 Jun 26;22(6):e19659. doi: 10.2196/19659.

  PMID: 32558655 BACKGROUND

• Norman CD, Skinner HA. eHealth Literacy: Essential Skills for Consumer Health in a Networked World. J Med Internet Res. 2006 Jun 16;8(2):e9. doi: 10.2196/jmir.8.2.e9.

  PMID: 16867972 BACKGROUND

• Hu D, Martin C, Dredze M, Broniatowski DA. Chinese social media suggest decreased vaccine acceptance in China: An observational study on Weibo following the 2018 Changchun Changsheng vaccine incident. Vaccine. 2020 Mar 17;38(13):2764-2770. doi: 10.1016/j.vaccine.2020.02.027. Epub 2020 Feb 22.

  PMID: 32093982 BACKGROUND

• Chen L, Wang X, Peng TQ. Nature and Diffusion of Gynecologic Cancer-Related Misinformation on Social Media: Analysis of Tweets. J Med Internet Res. 2018 Oct 16;20(10):e11515. doi: 10.2196/11515.

  PMID: 30327289 BACKGROUND

• Keelan J, Pavri V, Balakrishnan R, Wilson K. An analysis of the Human Papilloma Virus vaccine debate on MySpace blogs. Vaccine. 2010 Feb 10;28(6):1535-40. doi: 10.1016/j.vaccine.2009.11.060. Epub 2009 Dec 8.

  PMID: 20003922 BACKGROUND

• Zimet GD, Rosberger Z, Fisher WA, Perez S, Stupiansky NW. Beliefs, behaviors and HPV vaccine: correcting the myths and the misinformation. Prev Med. 2013 Nov;57(5):414-8. doi: 10.1016/j.ypmed.2013.05.013. Epub 2013 May 31.

  PMID: 23732252 BACKGROUND

• Huang Y, Xu S, Xu Y, Yao D, Wang L, Zhao Y, Wu Q. A New Strategy for Cervical Cancer Prevention Among Chinese Women: How Much Do They Know and How Do They React Toward the HPV Immunization? J Cancer Educ. 2021 Apr;36(2):386-394. doi: 10.1007/s13187-019-01642-y.

  PMID: 31902089 BACKGROUND

• Zhang Y, Wang Y, Liu L, Fan Y, Liu Z, Wang Y, Nie S. Awareness and knowledge about human papillomavirus vaccination and its acceptance in China: a meta-analysis of 58 observational studies. BMC Public Health. 2016 Mar 3;16:216. doi: 10.1186/s12889-016-2873-8.

  PMID: 26936076 BACKGROUND

• Li K, Li Q, Song L, Wang D, Yin R. The distribution and prevalence of human papillomavirus in women in mainland China. Cancer. 2019 Apr 1;125(7):1030-1037. doi: 10.1002/cncr.32003. Epub 2019 Feb 12.

  PMID: 30748006 BACKGROUND

• Li C, Wu M, Wang J, Zhang S, Zhu L, Pan J, Zhang W. A population-based study on the risks of cervical lesion and human papillomavirus infection among women in Beijing, People's Republic of China. Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2655-64. doi: 10.1158/1055-9965.EPI-10-0212. Epub 2010 Aug 18.

  PMID: 20719907 BACKGROUND

• Zhao FH, Lin MJ, Chen F, Hu SY, Zhang R, Belinson JL, Sellors JW, Franceschi S, Qiao YL, Castle PE; Cervical Cancer Screening Group in China. Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China. Lancet Oncol. 2010 Dec;11(12):1160-71. doi: 10.1016/S1470-2045(10)70256-4. Epub 2010 Nov 11.

  PMID: 21075054 BACKGROUND

• Li X, Xiang F, Dai J, Zhang T, Chen Z, Zhang M, Wu R, Kang X. Prevalence of cervicovaginal human papillomavirus infection and genotype distribution in Shanghai, China. Virol J. 2022 Sep 12;19(1):146. doi: 10.1186/s12985-022-01879-y.

  PMID: 36096810 BACKGROUND

MeSH Terms

Conditions

Communication

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Zhiyuan Hou, PhD

  Fudan University

  PRINCIPAL INVESTIGATOR

• Leesa Lin, PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zhiyuan Hou, PhD

CONTACT

86+21 33563935; zyhou@fudan.edu.cn

Leesa Lin, PhD

CONTACT

+852 39103770; leesalin@hku.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 26, 2024
• First Posted: May 8, 2024
• Study Start: April 28, 2024
• Primary Completion: May 31, 2024
• Study Completion: June 30, 2024
• Last Updated: May 8, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Beginning 12 months and ending 36 months following article publication
• Access Criteria: Researchers who provide a methodologically sound proposal for meta analysis. Proposals should be directed to zyhou@fudan.edu.cn; to gain access, data requestors will need to sign a data access agreement.

Locations

CN (2)