Effectiveness of Vaccine Chatbot on HPV Vaccine Awareness and Vaccination in China

NCT06227689 | Recruiting

• 1 other identifier: FudanU-HPV Chatbot
• Study Type: interventional
• Target: 1,800
• Locations: 1 country
• Sites: 2

Brief Summary

This interventional study targets female students in junior middle school. It goal is to evaluate the effectiveness of a vaccine chatbot on HPV vaccine awareness and vaccination. The main questions it aims to answer are:

1. 1.How will the novel digital tool, a vaccine chatbot, impact eligible parents' awareness and knowledge of HPV vaccines, their willingness to vaccinate their daughters, and vaccination status of female students.
2. 2.How is the vaccine chatbots accepted by all stakeholders, and what are the facilitators of and barriers to implementing vaccine chatbot promotion campaign.
3. 3.The intervention group will be invited to use the HPV vaccine chatbot online through WeChat , the mostly widely used social media platform in mainland China, or any web browsers. They can ask any questions related to the HPV vaccine and get validated answers from the chatbot immediately. The intervention lasts two weeks, with invitations sent every four days to reinforce the intervention.
4. 4.The control group will not use the chatbot during the intervention duration.

Conditions

HPV Vaccine

Keywords

HPV vaccine; awareness; knowledge; vaccination; vaccine confidence

Outcome Measures

Primary Outcomes (1)

• HPV vaccination status and appointment

  whether participants' daughters get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

  Two weeks and four months after the baseline

Secondary Outcomes (5)

• Willingness to vaccinate

  Two weeks between baseline and follow-up surveys

• HPV vaccine awareness and knowledge

  Two weeks between baseline and follow-up surveys

• HPV vaccine confidence

  Two weeks between baseline and follow-up surveys

• Healthcare consultation

  Two weeks after the baseline

• Chatbot Usability

  Two weeks after the baseline

Study Arms (2)

HPV Chatbot Intervention group

EXPERIMENTAL

In this arm, participants will receive a vaccine chatbot intervention. They will be invited to use the HPV vaccine chatbot online through WeChat or any web browsers, where they can ask any questions related to the HPV vaccine and get immediate answers from the chatbot. The intervention lasts two weeks, with invitations sent every four days to reinforce the intervention.

Other: Vaccine chatbot that offering HPV vaccine-related information

Control group

NO INTERVENTION

The control group will not use the chatbot during the intervention duration.

Interventions

Vaccine chatbot that offering HPV vaccine-related information OTHER

The intervention group will be invited to use the HPV vaccine chatbot online through WeChat or any web browsers, where they can ask any questions related to the HPV vaccine and get previously validated answers from the chatbot immediately. All the answers will be drawn from a database, whose content were obtained from official websites of Chinese government, HPV vaccine enterprises, and International organizations like WHO, and had been validated by experts. The intervention lasts two weeks, with invitations sent every four days to reinforce the intervention.

HPV Chatbot Intervention group

Eligibility Criteria

• Age: 10 Years - 16 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Parents of female students in middle school;
• The students not vaccinated or appointed for HPV vaccination and without contraindications to HPV vaccines;
• Without mental disorders or visual/reading impairments, and able to cooperate with and undergo the intervention activities;
• Obtained informed consent and willing to participate in the study.

You may not qualify if:

• Students vaccinated or appointed for HPV vaccination or with any contraindication to HPV vaccines;
• With mental disorders or visual/reading impairments, and unable to cooperate with and undergo the intervention activities;
• Unwilling to participate.

Sponsors & Collaborators

• Fudan University: lead
• The University of Hong Kong: collaborator

Study Sites (2)

Chizhou Health Center for Disease Control and Prevention

Chizhou, Anhui, 247100, China

RECRUITING

Jiading District Center for Disease Control and Prevention

Shanghai, Shanghai Municipality, China

RECRUITING

Related Publications (24)

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• 宋祎凡,刘晓雪,尹遵栋,等.2018-2020年中国9-45岁女性人乳头瘤病毒疫苗估算接种率[J].中国疫苗和免疫,2021,27(05):570-575.

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  RESULT

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  RESULT

• Hou Z, Wu Z, Qu Z, Gong L, Peng H, Jit M, Larson HJ, Wu JT, Lin L. A vaccine chatbot intervention for parents to improve HPV vaccination uptake among middle school girls: a cluster randomized trial. Nat Med. 2025 Jun;31(6):1855-1862. doi: 10.1038/s41591-025-03618-6. Epub 2025 Apr 7.

  PMID: 40195450 DERIVED

Related Links

• World Health Organization. Human papillomavirus vaccines: WHO position paper (2022 update). Weekly Epidemiological Record. 2022, 97 (50), 645-672.
• World Health Organization. Behavioural and social drivers of vaccination: tools and practical guidance for achieving high uptake

Study Officials

• Zhiyuan Hou, PhD

  School of Public Health，Fudan University

  PRINCIPAL INVESTIGATOR

• Leesa Lin, PhD

  School of Public Health, The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zhiyuan Hou, PhD

CONTACT

86+21 33563935; zyhou@fudan.edu.cn

Leesa Lin, PhD

CONTACT

+852 39103770; leesalin@hku.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 18, 2024
• First Posted: January 29, 2024
• Study Start: January 18, 2024
• Primary Completion: June 30, 2024
• Study Completion: July 31, 2024
• Last Updated: June 12, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Beginning 12 months and ending 36 months following article publication
• Access Criteria: Researchers who provide a methodologically sound proposal for meta-analysis. Proposals should be directed to zyhou@fudan.edu.cn; to gain access, data requestors will need to sign a data access agreement.

Locations

CN (2)