NCT07489014

Brief Summary

The study will include a total of 40 individuals aged 18-65 years with chronic neck pain for at least three months. Participants will be randomly assigned to two groups: the Mulligan mobilization group (n=20) and the AYDM group (n=20). Both groups will receive a total of 12 treatment sessions, 3 days a week for 4 weeks. Assessments will be performed before and after treatment. Pain intensity will be assessed using the Visual Analog Scale (VAS), cervical awareness using the Fremantle Neck Awareness Questionnaire (FNA), and functionality using the Copenhagen Neck Functional Disability Scale (CNFDS). In addition, measurements of cervical joint range of motion, deep neck flexor muscle endurance, quality of life (SF-36), and depression level (Beck Depression Scale) will be taken.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Mar 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 13, 2026

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

March 15, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

March 23, 2026

Completed
9 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2026

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2026

Completed
Last Updated

March 23, 2026

Status Verified

March 1, 2026

Enrollment Period

19 days

First QC Date

March 15, 2026

Last Update Submit

March 18, 2026

Conditions

Neck Pain

Keywords

neck painmulliganinstrument-assisted soft tissue mobilizationcervical awarenessfunctionpain

Outcome Measures

Primary Outcomes (4)

  • Pain Intensity

    Visual Pain Scale.Participants' pain intensity will be assessed using the Visual Analog Scale (VAS). The Visual Analog Scale is a validated and reliable scale that quantitatively determines the intensity of pain perceived by an individual. The scale consists of a 10 cm long horizontal or vertical line, with one end of the line defined as "0 = no pain" and the other end as "10 = unbearable pain".

    Baseline and at the end of treatment (week 4)

  • Range of motion

    To assess the active range of motion of the cervical joint, the tape measure method described by Hsieh et al. (1986) was used. This method is reported to be a practical and reliable measurement tool for assessing cervical range of motion in clinical practice.

    Baseline and at the end of treatment (week 4)

  • Cervical awareness

    Fremantle Neck Awareness Questionnaire

    Baseline and at the end of treatment (week 4)

  • Copenhagen Neck Functional Disability Scale

    Neck Functional Disability is a 15-item questionnaire. Total score(0-30) indicate higher disability

    Baseline and at the end of treatment (week 4)

Secondary Outcomes (3)

  • Neck flexor endurance

    Baseline and at the end of treatment (week 4)

  • SF-36 Quality of life

    Baseline and at the end of treatment (week 4)

  • Depression Scale

    Baseline and at the end of treatment (week 4)

Study Arms (2)

Mulligan

ACTIVE COMPARATOR

In line with the Mulligan Concept, natural apophyseal gliding (NAGs) and sustained natural apophyseal gliding (SNAGs) techniques will be applied.

Other: Mobilization

Instrumental Soft Tissue Mobilization

ACTIVE COMPARATOR

In the Instrumental Soft Tissue Mobilization (ITSM) group, participants will undergo bilateral procedures on the upper and middle trapezius muscles, levator scapulae, sternocleidomastoid (SCM), anterior, medius and posterior scalene muscle groups, erector spine, and suboccipital muscles.

Other: Instrumental Soft Tissue Mobilization

Interventions

Instrumental Soft Tissue MobilizationOTHER

The treatments will administered 3 days a week for a total of 12 sessions over 4 weeks.

Instrumental Soft Tissue Mobilization
MobilizationOTHER

The treatments will administered 3 days a week for a total of 12 sessions over 4 weeks.

Mulligan

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Volunteering to participate in the study
  • Being between 18 and 65 years of age
  • Having experienced mechanical neck pain for at least 3 months
  • Not having any contraindications for manual therapy

You may not qualify if:

  • Receiving a diagnosis of a psychiatric illness
  • Having a history of spinal surgery
  • Having other musculoskeletal problems that may affect the cervical region (such as scoliosis, shoulder pathologies, thoracic outlet syndrome)
  • Having received physiotherapy for neck and back problems within the last year.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Istanbul Rumeli University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Neck PainPain

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor physiotherapist

Study Record Dates

First Submitted

March 15, 2026

First Posted

March 23, 2026

Study Start

March 13, 2026

Primary Completion

April 1, 2026

Study Completion

April 30, 2026

Last Updated

March 23, 2026

Record last verified: 2026-03

Locations

TU(1)