Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery

NCT07488182 | Not Yet Recruiting

• 1 other identifier: 2026/6334
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for post-induction hypotension in adult patients undergoing elective non-cardiac surgery under general anesthesia. Hemodynamic instability during anesthesia induction is a common and clinically important problem associated with adverse perioperative outcomes. Carotid Doppler ultrasonography provides a rapid and non-invasive method for assessing hemodynamic status at the bedside. In this study, carotid Doppler measurements will be performed in the preoperative period and their association with post-induction hypotension will be analyzed. The results of this study may help identify patients at risk for hypotension and improve perioperative hemodynamic management.

Conditions

Post Induction Hypotension; Postoperative Morbidity

Keywords

Doppler Ultrasound; Velocity Time Integral; Anesthesia

Outcome Measures

Primary Outcomes (1)

• Post-induction hypotension

  Occurrence of post-induction hypotension after anesthesia induction, defined as either a decrease in mean arterial pressure (MAP) of ≥30% from baseline or a MAP \<65 mmHg sustained for at least 1 minute.

  From anesthesia induction until 10 minutes after tracheal intubation or until the start of surgery, whichever occurs first.

Secondary Outcomes (1)

• Predictive performance of carotid Doppler parameters

  From the initiation of anesthetic induction until 10 minutes after tracheal intubation or until surgical incision, whichever occurs first.

Study Arms (1)

Elective Non-Cardiac Surgery Patients

Patients undergoing elective non-cardiac surgery will be prospectively enrolled. Preoperative carotid Doppler ultrasonography parameters, including carotid velocity time integral (VTI) and corrected carotid flow time (ccFT), will be measured before anesthesia induction. No intervention will be applied as part of the study protocol. Patients will be followed for the occurrence of post-induction hypotension after standardized anesthesia induction.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18-65 years with American Society of Anesthesiologists (ASA) physical status I-II who are scheduled for elective non-cardiac surgery under general anesthesia will be included in this study.

You may qualify if:

• Adult patients aged 18-65 years
• American Society of Anesthesiologists (ASA) physical status I-II
• Scheduled for elective non-cardiac surgery under general anesthesia
• Planned endotracheal intubation
• Ability to provide written informed consent

You may not qualify if:

• Refusal to participate in the study
• Planned emergency surgery
• Planned cardiac surgery
• Presence of carotid artery stenosis greater than 50%
• Moderate to severe valvular heart disease
• Presence of atrial fibrillation or significant arrhythmia
• Advanced heart failure
• Preoperative hypotension or hemodynamic instability
• Inability to obtain reliable ultrasonographic measurements

Sponsors & Collaborators

• Necmettin Erbakan University: lead

Study Sites (1)

Necmettin Erbakan University

Konya, Turkey (Türkiye)

Location

Related Publications (4)

• Mascha EJ, Yang D, Weiss S, Sessler DI. Intraoperative Mean Arterial Pressure Variability and 30-day Mortality in Patients Having Noncardiac Surgery. Anesthesiology. 2015 Jul;123(1):79-91. doi: 10.1097/ALN.0000000000000686.

  PMID: 25929547 BACKGROUND

• Blanco P

  BACKGROUND

• Cheong I, Otero Castro V, Sosa FA, Tort Oribe B, Fruchtenicht MF, Tamagnone FM, Merlo PM. Passive leg raising test using the carotid flow velocity-time integral to predict fluid responsiveness. J Ultrasound. 2024 Mar;27(1):97-104. doi: 10.1007/s40477-023-00824-1. Epub 2023 Sep 5.

  PMID: 37668901 BACKGROUND

• Cheong I, Otero Castro V, Sosa FA, Tort Oribe B, Merlo PM, Tamagnone FM. Carotid flow as a surrogate of the left ventricular stroke volume. J Clin Monit Comput. 2023 Apr;37(2):661-667. doi: 10.1007/s10877-022-00938-7. Epub 2022 Nov 18.

  PMID: 36399216 BACKGROUND

Central Study Contacts

Engin Kılınç, Medical Doctor

CONTACT

00 90 332 223 60 00; enginkilinc96@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc.Prof.MD

Study Record Dates

• First Submitted: March 17, 2026
• First Posted: March 23, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: March 23, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)