Wearable Accelerometers for Predicting Perioperative Risk in Elderly Patients

NCT07621120 | Recruiting DMC

• 1 other identifier: PUMCHAIIT-2025-09
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This single-center prospective cohort study is designed to evaluate whether preoperative physical activity measured by a wearable accelerometer is associated with cardiovascular autonomic function and whether it can help predict post-induction hypotension in elderly patients undergoing elective non-cardiac surgery. Patients aged 65 years or older scheduled for general anesthesia with tracheal intubation will undergo preoperative physical activity monitoring using an ActiGraph wearable accelerometer. Activity-related parameters, including sedentary time, light-, moderate-, and vigorous-intensity activity, daily step count, and sleep duration, will be recorded. Cardiovascular autonomic function will be assessed perioperatively using noninvasive continuous hemodynamic monitoring, with baroreflex sensitivity-related indices derived from continuous blood pressure and beat-to-beat timing data. The primary outcome is post-induction hypotension. Secondary outcomes include early intraoperative hypotension, postoperative complications, and 30-day mortality. This study aims to clarify the relationship between habitual physical activity and autonomic regulation in older surgical patients and to provide evidence supporting future prehabilitation strategies.

Conditions

Post Induction Hypotension

Keywords

post induction hypotension; elderly patient; wearable accelerometer

Outcome Measures

Primary Outcomes (2)

• Post induction hypotension

  Systolic blood pressure less than 90 mmHg, mean arterial pressure less than 65 mmHg, or a decrease of more than 30% from baseline.

  Within 20 minutes after induction of anesthesia or before surgical incision.

• Early intraoperative hypotension

  Systolic blood pressure less than 90 mmHg, mean arterial pressure less than 65 mmHg, or a decrease of more than 30% from baseline.

  Within 30 minutes after incision

Secondary Outcomes (1)

• Postoperative complications

  Within 30 days after surgery

Study Arms (1)

observational group

all of enrolled patients

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly patients who will undergo general anesthesia surgery in Peking Union Medical College Hospital.

You may qualify if:

• Age ≥65 years
• Scheduled for elective non-cardiac surgery
• American Society of Anesthesiologists (ASA) physical status I-III
• Planned to undergo general anesthesia
• Planned tracheal intubation
• The patient and family members are able to understand the study protocol, are willing to participate, and provide written informed consent

You may not qualify if:

• Severe vascular disease
• Secondary hypertension
• Limb tremor disorders, such as Parkinson disease
• Inability to wear a wrist-based wearable accelerometer for any reason
• Inability to measure upper-extremity blood pressure
• Atrial fibrillation or other arrhythmias unsuitable for baroreflex sensitivity measurement
• Mental or psychiatric conditions resulting in inability to cooperate with study procedures

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China

RECRUITING

Related Publications (2)

• Finet M, Bellicha A, Sage E, Glorion M, Kennel T, Labro M, Trillat B, Fischler M, Vallee A, Le Guen M, Fessler J. Comprehensive assessment of postoperative mobility during the first days after mini-invasive lung surgery: A prospective observational study. J Clin Anesth. 2023 Jun;86:111048. doi: 10.1016/j.jclinane.2022.111048. Epub 2023 Jan 28.

  PMID: 36716650 BACKGROUND

• Gardenghi G, Rondon MU, Braga AM, Scanavacca MI, Negrao CE, Sosa E, Hachul DT. The effects of exercise training on arterial baroreflex sensitivity in neurally mediated syncope patients. Eur Heart J. 2007 Nov;28(22):2749-55. doi: 10.1093/eurheartj/ehm208. Epub 2007 Jun 7.

  PMID: 17561494 BACKGROUND

Central Study Contacts

Quexuan Cui

CONTACT

13520921711; Cuiqx_garfield@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 25, 2026
• First Posted: June 2, 2026
• Study Start: June 15, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: June 2, 2026

Record last verified: 2026-04

Locations

CN (1)