Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older

NCT07487610 | Recruiting

• 1 other identifier: 29/12/2025-Number:13/33
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to determine the frequency of neuropathic pain in individuals aged 80 years and older and to evaluate the relationship between neuropathic pain and comprehensive geriatric assessment parameters.

Conditions

Neuropathic Pain; Old Age; Debility; Pain

Outcome Measures

Primary Outcomes (1)

• Presence of neuropathic pain

  The presence of neuropathic pain will be assessed using the Douleur Neuropathique-4 (DN4) questionnaire. The DN4 consists of 10 items. The first 7 items evaluate the characteristics and sensory quality of pain, whereas the remaining 3 items are based on physical examination findings. A total score of 4 or higher is defined as the presence of neuropathic pain, while a score below 4 is defined as the absence of neuropathic pain.

  Baseline

Secondary Outcomes (7)

• Pain intensity

  Baseline

• Mood status

  Baseline

• Daily living activities

  Baseline

• Activities of daily living

  Baseline

• Neurocognitive assessment

  Baseline

Study Arms (2)

patients without neuropathic pain

Patients with a total score of 4 or higher according to the Douleur Neuropathique 4 (DN4)

Other: Detailed geriatric assessment

Patients without neuropathic pain

Patients with a total DN4 score below 4

Other: Detailed geriatric assessment

Interventions

Detailed geriatric assessment OTHER

The patients' demographic characteristics, comorbid diseases, and laboratory parameters routinely requested from each patient within the last 3 months, including TSH, vitamin D, vitamin B12, HbA1c, hemoglobin, folic acid, and GFR levels, will be recorded. During the outpatient clinic visit, the presence of neuropathic pain will be assessed using the Douleur Neuropathique-4 (DN4) questionnaire. Pain intensity will be evaluated using the Visual Analog Scale (VAS), and the average pain severity over the last week will be recorded. The use of medications that may affect pain severity and that have been used regularly by the patients for the last 3 months will also be assessed (antiepileptics, nonsteroidal anti-inflammatory drugs, paracetamol, and antidepressants). The patients will undergo mood assessment, evaluation of basic and instrumental activities of daily living, neurocognitive assessment, frailty assessment, and nutritional assessment.

Patients without neuropathic pain; patients without neuropathic pain

Eligibility Criteria

• Age: 80 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 80 and over who are followed up from the healthy aging outpatient clinic of Edirne Sultan 1. Murat State Hospital geriatric clinic will be included in the study

You may qualify if:

• Age 80 years or older
• Full cooperation
• Complete comprehensive geriatric assessment parameters

You may not qualify if:

• Patients with dementia classified as CDR-2 or CDR-3 according to the Clinical Dementia Rating (CDR) Scale
• Patients who have experienced an acute illness within the last 1 month (e.g., infection, fracture, or cerebrovascular disease)
• Patients with a psychotic disorder
• Patients with severe hearing loss
• Patients with a history of malignancy

Sponsors & Collaborators

• Sultan 1. Murat State Hospital: lead

Study Sites (1)

Sultan 1. Murat State Hospital

Edirne, 22030, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Neuralgia; Frailty; Pain

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Study Officials

• Kübra Altunkalem Seydi, MD

  Sultan 1. Murat State Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alper Mengi, MD

CONTACT

+90 537 651 03 85; dralpmengi@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 17, 2026
• First Posted: March 23, 2026
• Study Start: March 17, 2026
• Primary Completion: May 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: March 23, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)