Personalized Mobile Reminders for Medication Adherence and Intraocular Pressure Control in Primary Open-Angle Glaucoma

NCT07480577 | Not Yet Recruiting

• 1 other identifier: 2026/1
• Study Type: interventional
• Target: 84
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study evaluates whether a personalized mobile reminder program improves treatment adherence and clinical outcomes in adults with primary open-angle glaucoma (POAG) using topical antiglaucoma eye drops. Poor adherence to long-term eye-drop therapy is common in glaucoma care and may contribute to inadequate intraocular pressure (IOP) control and disease progression. Participants are randomized to either (1) a digital adherence intervention or (2) standard outpatient follow-up. The intervention consists of daily interactive SMS/WhatsApp medication reminders plus weekly brief educational messages for 3 months. The primary outcome is change in medication adherence measured by the Morisky Medication Adherence Scale-8 (MMAS-8) at month 3. Secondary outcomes include change in IOP, eye-drop instillation technique, and treatment satisfaction. Exploratory analyses assess the relationship between adherence level and OCT-based retinal nerve fiber layer (RNFL) progression metrics. The goal is to determine whether a low-cost, scalable mobile strategy can improve short-term glaucoma management in routine practice.

Conditions

Primary Open-Angle Glaucoma (POAG)

Keywords

Primary Open-Angle Glaucoma; Medication Adherence; Mobile Reminder; SMS Reminder; WhatsApp Reminder; MMAS-8

Outcome Measures

Primary Outcomes (1)

• Change in Medication Adherence

  Difference in Morisky Medication Adherence Scale-8 (MMAS-8) total score from baseline to month 3, and between-group comparison of mean change. Higher scores indicate better adherence.

  Baseline and Month 3

Secondary Outcomes (1)

• Change in Intraocular Pressure (IOP)

  Baseline and Month 3

Other Outcomes (1)

• Association Between Adherence Level and OCT-Derived RNFL Progression Metrics

  Retrospective OCT data up to Month 3 assessment

Study Arms (2)

Digital Reminder Intervention

EXPERIMENTAL

Participants receive a personalized mobile adherence program in addition to standard glaucoma care, including daily interactive SMS/WhatsApp medication reminders and weekly brief educational messages for 3 months.

Behavioral: Digital Reminder Intervention

Standard Care

NO INTERVENTION

Participants receive routine outpatient glaucoma follow-up and prescribed topical antiglaucoma treatment without digital reminders.

Interventions

Digital Reminder Intervention BEHAVIORAL

A behavioral adherence support intervention consisting of daily interactive SMS/WhatsApp reminders for eye-drop use and weekly educational reinforcement messages over 3 months.

Digital Reminder Intervention

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 to 75 years. Diagnosis of primary open-angle glaucoma (POAG) in at least one eye. Currently treated with at least one topical antiglaucoma medication. Able to read and understand study procedures and provide written informed consent.
• Has regular access to a mobile phone capable of receiving SMS or WhatsApp messages.
• Willing to comply with follow-up visits and study procedures for 3 month

You may not qualify if:

• Secondary glaucoma (e.g., neovascular, uveitic, steroid-induced) or angle-closure glaucoma.
• Ocular surgery or laser procedure within the previous 3 months, or planned ocular surgery during study follow-up.
• Advanced ocular comorbidity likely to affect IOP assessment or adherence evaluation (e.g., severe corneal disease, active ocular infection/inflammation).
• Cognitive impairment, severe psychiatric disease, or communication barriers that prevent reliable participation.
• Inability to use or access mobile messaging tools required for the intervention.
• Participation in another interventional clinical study that may interfere with outcomes

Sponsors & Collaborators

• Sakarya Yenikent State Hospital: lead

MeSH Terms

Conditions

Glaucoma, Open-Angle; Medication Adherence

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: This is an open-label behavioral intervention trial. Participants and treating clinicians are aware of assignment due to the nature of the mobile reminder intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Yenikent State Hospital, Head of Ophthalmology

Model Details: Participants are randomized in a 1:1 ratio to either a personalized mobile reminder intervention (daily interactive SMS/WhatsApp reminders plus weekly educational messages) or standard outpatient follow-up for 3 months.

Study Record Dates

• First Submitted: March 14, 2026
• First Posted: March 18, 2026
• Study Start: April 1, 2026
• Primary Completion: July 1, 2026
• Study Completion: August 1, 2026
• Last Updated: March 18, 2026

Record last verified: 2026-03