Role of Peripheral Vision in Scene Perception (PERISCE)

NCT05539508 | Not Yet Recruiting

• 1 other identifier: 2021-A01986-35
• Study Type: observational
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.

Conditions

Primary Open-angle Glaucoma (POAG)

Outcome Measures

Primary Outcomes (2)

• Psychophysical measure : Percentage of correct response

  Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment

  Through study completion of 45 months

• Psychophysical measure : Mean reaction time in milliseconds

  Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment

  Through study completion of 45 months

Study Arms (2)

Primary open-angle glaucoma (POAG) group

Behavioral: Psychophysical evaluation

Age-matched normally sighted control group

Behavioral: Psychophysical evaluation

Interventions

Psychophysical evaluation BEHAVIORAL

All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard.

Age-matched normally sighted control group; Primary open-angle glaucoma (POAG) group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

POAG patients and age-matched normally sighted controls

You may qualify if:

• For patients :
• between 18 and 80 years old
• stable bilateral primary open angle glaucoma (POAG)
• visual acuity \> 5/10 for distant vision for the eye tested
• peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer
• For healthy volunteers :
• between 18 and 80 years old
• visual acuity \> 5/10
• absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)

You may not qualify if:

• ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)
• treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Sponsors & Collaborators

• University Hospital, Grenoble: lead

Related Publications (3)

• Roux-Sibilon A, Rutge F, Aptel F, Attye A, Guyader N, Boucart M, Chiquet C, Peyrin C. Scene and human face recognition in the central vision of patients with glaucoma. PLoS One. 2018 Feb 26;13(2):e0193465. doi: 10.1371/journal.pone.0193465. eCollection 2018.

  PMID: 29481572 BACKGROUND

• Roux-Sibilon A, Trouilloud A, Kauffmann L, Guyader N, Mermillod M, Peyrin C. Influence of peripheral vision on object categorization in central vision. J Vis. 2019 Dec 2;19(14):7. doi: 10.1167/19.14.7.

  PMID: 31826252 BACKGROUND

• Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Feb 11:1-15. doi: 10.1162/jocn_a_01689. Online ahead of print.

  PMID: 33571079 BACKGROUND

MeSH Terms

Conditions

Glaucoma, Open-Angle

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Central Study Contacts

Carole Peyrin, PhD

CONTACT

04 76 82 58 79; carole.peyrin@univ-grenoble-alpes.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 23, 2022
• First Posted: September 14, 2022
• Study Start: October 1, 2022
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2027
• Last Updated: September 14, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will share
• Time Frame: Data will become available after publications with no limit time
• Access Criteria: Link to the Open Science Framework