Vitamin D Status in Young Medical Residents

NCT07479303 | Completed

• 1 other identifier: VitD_6337
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Retrospective, observational, and anonymous study to assess vitamin D status in young medical residents of both sexes who joined the staff of the Reina Sofia University Hospital (HURS) in Cordoba, Spain, in March 2020. Subjects with vitamin D deficiency were treated with calcifediol and reevaluated. The retrospective cohort study was approved (October 29, 2025) by the Provincial Committee on Ethics in Drug Research (CEIm) of Córdoba (Spain), \[committee reference number 6337) Communication/application code: SICEIA-2025-002858\]. Data Based on the files of the HURS occupational medicine service.

Conditions

Vitamin D Deficiency

Keywords

Calcifediol; Cholecalciferol; Vitamin D; Vitamin D endocrine system; Vitamin D3; VDR Vitamin D; Vitamin D3-sulphate; 25(OH)D3-Sulphate; 25(OH)D- Glucuronide

Outcome Measures

Primary Outcomes (1)

• Vitamin D endocrine system

  Assess the status of the vitamin D endocrine system

  Change from Baseline in the 25OH vitamin D through study completion, an average of 1 year

Interventions

Calcifediol (Vitamin D) DRUG

They were evaluated at the start of the study and after oral treatment with calcidiol (Hidroferol® Faes-Farma, Spain).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Medical residents admitted to the Reina Sofia University Hospital Residency Program

You may qualify if:

• Physicians admitted to the Residency Programme at Reina Sofía University Hospital

You may not qualify if:

• Subjects for whom there is no data collected in the occupational medicine medical recordrds

Sponsors & Collaborators

• Maimónides Biomedical Research Institute of Córdoba: lead
• Hospital Universitario Reina Sofia de Cordoba: collaborator

Study Sites (1)

Hospital Universitario Reina Sofía, Edificio IMIBIC, Avd. Menedez Pidal, s/n

Córdoba, 14004, Spain

Location

Related Publications (14)

• Quesada-Gomez JM, Bouillon R. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int. 2018 Aug;29(8):1697-1711. doi: 10.1007/s00198-018-4520-y.

  BACKGROUND

• Bouillon R, Quesada Gomez JM. Comparison of calcifediol with vitamin D for prevention or cure of vitamin D deficiency. J Steroid Biochem Mol Biol. 2023 Apr; 228:106248. doi: 10.1016/j.jsbmb.2023.106248.

  BACKGROUND

• Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 Aug 1;40(4):1109-1151. doi: 10.1210/er.2018-00126.

  BACKGROUND

• Haney EM, Stadler D, Bliziotes MM. Vitamin D insufficiency in internal medicine residents. Calcif Tissue Int. 2005 Jan;76(1):11-6. doi: 10.1007/s00223-004-0025-0.

  BACKGROUND

• Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002 Jun 1;112(8):659-62. doi: 10.1016/s0002-9343(02)01091-4.

  BACKGROUND

• McKenna MJ. Differences in vitamin D status between countries in young adults and the elderly. Am J Med. 1992 Jul;93(1):69-77. doi: 10.1016/0002-9343(92)90682-2.

  BACKGROUND

• Calatayud M, Jódar E, Sánchez R, Guadalix S, Hawkins F. Prevalencia de concentraciones deficientes e insuficientes de vitamina D en una población joven y sana Endocrinol Nutr. 2009 Apr;56(4):164-9. doi: 10.1016/S1575-0922(09)70980-5.

  BACKGROUND

• Mata-Granados JM, Luque de Castro MD, Quesada Gomez JM Niveles séricos inadecuados de retinol, α-tocoferol, 25 hidroxivitamina D3 y 24,25 dihidroxivitamina D3 en adultos españoles sanos: valoración simultánea por HPLC. Clin. Biochem. 2008; 41 : 676-680. doi: 10.1016 / j.clinbiochem.2008.02.00

  BACKGROUND

• Navarro Valverde C, Quesada Gómez JM. Deficiencia de vitamina D en España. ¿Realidad o mito? Rev Osteoporos Metab Miner 2014; 6 (Supl1):S5-10 doi: 10.4321/S1889-836X2014000500002.

  BACKGROUND

• Gómez-Alonso C, Naves-Díaz ML, Fernández-Martín JL, Díaz-López JB, Fernández-Coto MT, Cannata-Andía JB. Vitamin D status and secondary hyperparathyroidism: the importance of 25-hydroxyvitamin D cut-off levels. Kidney Int Suppl. 2003 Jun;(85):S44-8. doi: 10.1046/j.1523-1755.63.s85.11.x.

  BACKGROUND

• González-Molero I, Morcillo S, Valdés S, Pérez-Valero V, Botas P, Delgado E, Hernández D, Olveira G, Rojo G, Gutierrez-Repiso C, Rubio-Martín E, Menéndez E, Soriguer F. Vitamin D deficiency in Spain: a population-based cohort study. Eur J Clin Nutr. 2011; 65: 321-8. doi: 10.1038/ejcn.2010.265.

  BACKGROUND

• Quesada-Gómez JM, Diaz-Curiel M, Sosa-Henriquez M, et al. Low calcium intake and inadequate vitamin D status in postmenopausal osteoporotic women. J Steroid Biochem Mol Biol. 2013; 136: 175-7. doi: 10.1016/j.jsbmb.2012.10.013

  BACKGROUND

• Hilger J, Friedel A, Herr R, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014; 111: 23-45. doi: 10.1017/S0007114513001840.

  BACKGROUND

• Giustina A, Bilezikian JP, Adler RA, Banfi G, Bikle DD, Binkley NC, Bollerslev J, Bouillon R, Brandi ML, Casanueva FF, di Filippo L, Donini LM, Ebeling PR, Fuleihan GE, Fassio A, Frara S, Jones G, Marcocci C, Martineau AR, Minisola S, Napoli N, Procopio M, Rizzoli R, Schafer AL, Sempos CT, Ulivieri FM, Virtanen JK. Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows. Endocr Rev. 2024 Sep 12;45(5):625-654. doi: 10.1210/endrev/bnae009.

  BACKGROUND

MeSH Terms

Conditions

Vitamin D Deficiency

Interventions

Calcifediol; Vitamin D

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Hydroxycholecalciferols; Cholecalciferol; Cholestenes; Cholestanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Sterols; Secosteroids; Membrane Lipids; Lipids

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2025
• First Posted: March 18, 2026
• Study Start: October 29, 2025
• Primary Completion: November 1, 2025
• Study Completion: December 1, 2025
• Last Updated: March 18, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: SAP

Locations

ES (1)