Vitamin D Status in Hemodialysis Transplant Candidates and Living Donors

NCT07409623 | Completed

• 1 other identifier: SBMU-12-1404/2
• Study Type: observational
• Target: 552
• Locations: 1 country
• Sites: 1

Brief Summary

Vitamin D, beyond its classical role in calcium and phosphate metabolism, is recognized as an important regulator of immune function and inflammation. Vitamin D deficiency is highly prevalent among patients with chronic kidney disease (CKD), particularly those receiving maintenance hemodialysis, and has been associated with adverse outcomes including mineral and bone disorders, increased susceptibility to infections, chronic inflammation, cardiovascular complications, and higher mortality. Despite the availability of international data, comprehensive local evidence in Iran comparing vitamin D status between hemodialysis patients listed for kidney transplantation and healthy living kidney donors is limited. This study aims to determine and compare serum 25-hydroxyvitamin D \[25(OH)D\] levels in these two groups and to evaluate their association with demographic characteristics, selected immunologic and inflammatory indicators, and clinical outcomes. This single-center cross-sectional analytical study will utilize data extracted from medical records. The results may provide scientific evidence to improve screening, prevention, and management strategies for vitamin D deficiency in hemodialysis patients awaiting kidney transplantation.

Conditions

Vitamin D Deficiency

Outcome Measures

Primary Outcomes (1)

• Prevalence of 25 hydroxyvitamin D deficiency and insufficiency

  proportion of participants with 25-hydroxyvitamin D deficiency (\<20ng/ml)and insufficiency (20-29 ng/ml)based on serum 25-hydroxyvitamin D concentration measured by laboratory assay.

  Baseline(Day 1)

Study Arms (2)

hemodialysis transplant candidates

To determine the prevalence of vitamin D deficiency and insufficiency

Diagnostic Test: VITAMIN D LEVEL

healthy living donors

To determine the prevalence of vitamin D deficiency and insufficiency

Diagnostic Test: VITAMIN D LEVEL

Interventions

VITAMIN D LEVEL DIAGNOSTIC_TEST

To determine the prevalence of vitamin D deficiency and insufficiency

Also known as: VITAMIN D

healthy living donors; hemodialysis transplant candidates

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Data Source: Retrospective extraction of medical records. Study Groups: * Hemodialysis patients listed for kidney transplantation. * Healthy living kidney donors. Main Study Variable: • Serum 25-hydroxyvitamin D \[25(OH)D\]. Demographic Variables: * Age * Sex Group Variable: • Clinical status (hemodialysis transplant candidate vs living donor).

You may qualify if:

• Hemodialysis patients listed for kidney transplantation.
• Healthy living kidney donors.

Sponsors & Collaborators

• Shahid Beheshti University of Medical Sciences: lead

Study Sites (1)

Nooshin Dalili

Tehran, 1666663421, Iran

Location

MeSH Terms

Conditions

Vitamin D Deficiency

Interventions

Vitamin D Response Element

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Response Elements; Enhancer Elements, Genetic; Regulatory Sequences, Nucleic Acid; Base Sequence; Molecular Structure; Biochemical Phenomena; Chemical Phenomena; Promoter Regions, Genetic; Genetic Structures; Genetic Phenomena; Regulatory Elements, Transcriptional; Gene Components; Genes; Genome Components; Genome

Study Officials

• SBMU SBMU

  SMBU

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Nephrology

Study Record Dates

• First Submitted: February 8, 2026
• First Posted: February 13, 2026
• Study Start: February 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: February 1, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)