Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency
BMR-VITD
Investigation of Postural Stability and Load-Sensitive Neuromuscular Control Mechanisms in Vitamin D Deficiency
1 other identifier
observational
24
1 country
1
Brief Summary
This observational study aims to investigate the relationship between vitamin D deficiency, postural stability, and neuromuscular control mechanisms in adults. The study will compare individuals with vitamin D deficiency and healthy controls. Participants will undergo a single-session evaluation including surface electromyography and postural stability assessments during standing tasks under different loading and vibration conditions. No invasive procedures, medications, or blood sampling will be performed. Previously obtained routine laboratory results will be used for vitamin D status. The study is designed to improve understanding of neuromuscular responses associated with vitamin D deficiency and to contribute to future rehabilitation strategies.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Mar 2026
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 21, 2026
CompletedFirst Posted
Study publicly available on registry
February 27, 2026
CompletedStudy Start
First participant enrolled
March 5, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 5, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
July 5, 2026
ExpectedMay 27, 2026
February 1, 2026
3 months
February 21, 2026
May 22, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Postural Stability Parameters
Postural stability parameters measured during single-leg and double-leg standing using force platform and surface electromyography, including postural sway and neuromuscular response variables.
Single assessment session (baseline)
Secondary Outcomes (2)
Neuromuscular Reflex and Muscle Activation Patterns
Single assessment session (baseline)
Effect of Loading and Vibration on Postural Control
Single assessment session (baseline)
Study Arms (2)
Vitamin D Deficiency Group
Participants with laboratory-confirmed vitamin D deficiency based on routine clinical test results. All participants will undergo standardized non-invasive postural stability and surface electromyography assessments in a single session.
Healthy Control Group
Participants with normal vitamin D status based on routine clinical test results and no history of balance or neuromuscular disorders. All participants will undergo standardized non-invasive postural stability and surface electromyography assessments in a single session.
Eligibility Criteria
Adults aged 20 to 40 years recruited from the outpatient clinics of Istanbul Physical Medicine and Rehabilitation Training and Research Hospital. Participants will include individuals with laboratory-confirmed vitamin D deficiency and healthy volunteers with normal vitamin D status.
You may qualify if:
- Age 20 to 40 years.
- Ability to provide written informed consent.
- Vitamin D deficiency group: serum 25-hydroxyvitamin D level \<10 ng/mL measured within the last 3 months (routine clinical testing).
- Healthy control group: normal vitamin D status based on routine clinical testing within the last 3 months.
- No use of vitamin D or calcium supplementation within the last 3 months.
You may not qualify if:
- Known metabolic bone disease other than vitamin D deficiency.
- Neurological disorder (central or peripheral) or neuromuscular disease.
- History of lower-limb surgery, fracture, or prosthesis affecting standing balance.
- Vestibular disorder.
- BMI \>30 kg/m2.
- Active malignancy.
- Severe psychiatric disorder.
- Skin condition preventing placement of surface EMG electrodes.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Istanbul, 34186, Turkey (Türkiye)
Related Publications (1)
Karacan I, Cakar HI, Sebik O, Yilmaz G, Cidem M, Kara S, Turker KS. A new method to determine reflex latency induced by high rate stimulation of the nervous system. Front Hum Neurosci. 2014 Jul 18;8:536. doi: 10.3389/fnhum.2014.00536. eCollection 2014.
PMID: 25100978RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Selim Sezikli, MD
Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Specialist in Physical Medicine and Rehabilitation
Study Record Dates
First Submitted
February 21, 2026
First Posted
February 27, 2026
Study Start
March 5, 2026
Primary Completion
June 5, 2026
Study Completion (Estimated)
July 5, 2026
Last Updated
May 27, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF
- Time Frame
- Supporting documents and de-identified individual participant data will be made available upon reasonable request after publication of the main results. Requests will be reviewed by the principal investigator and shared for academic purposes under a data use agreement.
- Access Criteria
- Access to de-identified individual participant data and supporting documents (study protocol, statistical analysis plan, and informed consent form) will be granted to qualified researchers upon reasonable request for academic and non-commercial purposes. Requests will be reviewed by the principal investigator. Data will be shared through secure electronic transfer under a data use agreement.
De-identified individual participant data will be shared upon reasonable request for academic and research purposes, after publication of the main results. Requests will be reviewed by the principal investigator and data will be provided under a data use agreement.