Muscle and Fat Mass in Preoperative Computed Tomography and a Neuromuscular Blocking Agent Dose

NCT07478120 | Completed

• 1 other identifier: B-2604-1036-102
• Study Type: observational
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Deep neuromuscular blockade has benefits in various surgical procedures and reduces postoperative pain. While neuromuscular blockade dosages are often based on the patient's actual body weight, body composition can vary significantly depending on age, gender, and individual exercise levels. Therefore, uniformly estimating neuromuscular blockade dosages based on actual body weight can result in under- or over-administered neuromuscular blocking agents. Calculating neuromuscular blockade dosage based on actual body weight can be inaccurate, but it remains due to the difficulty of accurately quantifying human muscle and fat mass. Recent advances in image analysis techniques utilizing artificial intelligence models have led to the development of methods for quantifying muscle and fat mass from computed tomography (CT). Theoretically, a higher neuromuscular blockade dosage should be required as the muscle mass increases. This study aims to analyze the relationship between neuromuscular blocking agent dosage, onset time, profound blockade time, and recovery time, and muscle mass and fat mass calculated from preoperative CT scans.

Conditions

Neuromuscular Blockade; Neuromuscular Blockade Monitoring

Outcome Measures

Primary Outcomes (1)

• muscle and fat mass

  subject's muscle and fat mass from preoperative computed tomography images.

  intraoperative period

Interventions

Neuromuscular block OTHER

Neuromuscular blockade monitoring

Eligibility Criteria

• Age: 19 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for elective gynecologic surgery under general anesthesia

You may qualify if:

• American Society of Anesthesiologists physical class (ASA class) 1-3
• Patients scheduled for elective gynecologic surgery under general anesthesia
• Patients undergoing abdominal computed tomography for routine preoperative preparation

You may not qualify if:

• Pregnant women
• Decreased renal function (GFR\<60mL/min/1.73m2).
• Patients taking drugs that affect deep neuromuscular blockade
• Patients with a history of neuromuscular and muscle disorders

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National University Bundang Hospital

Gyeonggi-do, Sungnamsi, 13620, South Korea

Location

MeSH Terms

Interventions

Neuromuscular Blockade

Intervention Hierarchy (Ancestors)

Anesthesia and Analgesia; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: March 12, 2026
• First Posted: March 17, 2026
• Study Start: January 1, 2021
• Primary Completion: February 28, 2021
• Study Completion: March 1, 2026
• Last Updated: March 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)