Examine the Epidemiology and Outcomes of Transitions From PD-to-HD in Canada

NCT07477210 | Active Not Recruiting

• 2 other identifiers: 2021-2531203760_1
• Study Type: observational
• Target: 17,000
• Locations: 1 country
• Sites: 1

Brief Summary

Transitions from peritoneal dialysis to hemodialysis are common during kidney replacement therapy and may be associated with adverse outcomes. However, the incidence, predictors, and outcomes of PD-to-HD transitions at a national level remain incompletely characterized. This study will use Canadian dialysis and hospitalization databases to examine the epidemiology and outcomes of PD-to-HD transitions among adults initiating dialysis in Canada. The study will evaluate transition incidence, predictors, and post-transition outcomes including mortality, transplantation, modality changes, and hospitalizations.

Conditions

Kidney Replacement Therapy; Peritoneal Dialysis (PD); Hemodialysis

Keywords

Transition; Transfer to hemodialysis

Outcome Measures

Primary Outcomes (1)

• Incidence of transfer from peritoneal dialysis to hemodialysis

  Measured as cumulative incidence and incidence rate of transitions following initiation of PD and censored at time of death, kidney transplantation, transfer home hemodialysis, or administrative end of follow-up.

  From PD initiation until 1-year after PD start Also assessed at from PD initation until 2- and 5-year after PD start.

Secondary Outcomes (3)

• All-cause mortality after transfer from peritoneal dialysis to hemodialysis

  From first day after transfer up to 1-year post transfert. Also assessed ad 2- and 5-year post transfer

• Return to Peritoneal Dialysis

  From first day after transfer to HD up to 180-day post transfer. Also measured at 90- and 365-day post transfer.

• Transfer to Home Hemodialysis

  From first day after transfer to HD until 180-day post transfer. Also measured at 90- and 365-day post transfer

Study Arms (1)

Patient receiving peritoneal dialysis with transfer to hemodialysis

Adults initiating dialysis in Canada between 2005 and 2018 who received peritoneal dialysis and experience a transfer to hemodialysis for 2 or more consecutive days.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults initiating dialysis in Canada between 2005 and 2018 who received peritoneal dialysis for at least 30 consecutive days, identified using the Canadian Organ Replacement Register (CORR) and linked administrative databases.

You may qualify if:

• Adults (≥18 years)
• Dialysis initiation in Canada between January 1, 2005 and December 31, 2018
• Peritoneal dialysis duration \>30 consecutive days

You may not qualify if:

• Dialysis initiation in Quebec or Manitoba during the study period
• Dialysis initiation in a foreign country
• Missing data on initial dialysis modality
• Pre-emptive kidney transplantation

Sponsors & Collaborators

• Ciusss de L'Est de l'Île de Montréal: lead

Study Sites (1)

CIUSSS de l'Est-de-l'ile de Montréal

Montreal, Quebec, H1T 2M4, Canada

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Nephrologist, Clinical Scientist

Study Record Dates

• First Submitted: February 20, 2026
• First Posted: March 17, 2026
• Study Start: January 1, 2005
• Primary Completion: December 31, 2019
• Study Completion (Estimated): December 1, 2027
• Last Updated: March 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)